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Cellosaurus SK-OV-3/CBP (CVCL_D621)

[Text version]
Cell line name SK-OV-3/CBP
Synonyms SKOV3/CBP; S-car
Accession CVCL_D621
Resource Identification Initiative To cite this cell line use: SK-OV-3/CBP (RRID:CVCL_D621)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:31355; Carboplatin (CBP; Paraplatin).
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; 583; APC; Simple; p.Thr1556Leufs*9 (c.4666delA); ClinVar=VCV000156477; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 16712; FBXW7; Simple; p.Arg505Leu (c.1514G>T); ClinVar=VCV000376424; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Ser90Profs*33 (c.267delC); ClinVar=VCV000156515; Zygosity=Homozygous (from parent cell line).
Disease Ovarian serous cystadenocarcinoma (NCIt: C7978)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0532 (SK-OV-3)
Sex of cell Female
Age at sampling 64Y
Category Cancer cell line

PubMed=15254775; DOI=10.3892/ijmm.14.2.257
Li L., Luan Y., Wang G., Tang B., Li D., Zhang W., Li X., Zhao J., Ding H., Reed E., Li Q.Q.
Development and characterization of five cell models for chemoresistance studies of human ovarian carcinoma.
Int. J. Mol. Med. 14:257-264(2004)

PubMed=17269733; DOI=10.1021/pr060402r
Yan X.-D., Pan L.-Y., Yuan Y., Lang J.-H., Mao N.
Identification of platinum-resistance associated proteins through proteomic analysis of human ovarian cancer cells and their platinum-resistant sublines.
J. Proteome Res. 6:772-780(2007)

Cell line databases/resources cancercelllines; CVCL_D621
Encyclopedic resources Wikidata; Q54954499
Entry history
Entry creation22-Oct-2012
Last entry update05-Oct-2023
Version number22