Cell line name |
SK-OV-3/CBP |
Synonyms |
SKOV3/CBP; S-car |
Accession |
CVCL_D621 |
Resource Identification Initiative |
To cite this cell line use: SK-OV-3/CBP (RRID:CVCL_D621) |
Comments |
Population: Caucasian. Selected for resistance to: ChEBI; CHEBI:31355; Carboplatin (CBP; Paraplatin). Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795. |
Sequence variations |
- Mutation; HGNC; 583; APC; Simple; p.Thr1556Leufs*9 (c.4666delA); ClinVar=VCV000156477; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 16712; FBXW7; Simple; p.Arg505Leu (c.1514G>T); ClinVar=VCV000376424; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Ser90Profs*33 (c.267delC); ClinVar=VCV000156515; Zygosity=Homozygous (from parent cell line).
|
Disease |
Ovarian serous cystadenocarcinoma (NCIt: C7978) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_0532 (SK-OV-3) |
Sex of cell |
Female |
Age at sampling |
64Y |
Category |
Cancer cell line |
Publications | PubMed=15254775; DOI=10.3892/ijmm.14.2.257 Li L., Luan Y., Wang G., Tang B., Li D., Zhang W., Li X., Zhao J., Ding H., Reed E., Li Q.Q. Development and characterization of five cell models for chemoresistance studies of human ovarian carcinoma. Int. J. Mol. Med. 14:257-264(2004) PubMed=17269733; DOI=10.1021/pr060402r Yan X.-D., Pan L.-Y., Yuan Y., Lang J.-H., Mao N. Identification of platinum-resistance associated proteins through proteomic analysis of human ovarian cancer cells and their platinum-resistant sublines. J. Proteome Res. 6:772-780(2007) |
Cross-references |
Cell line databases/resources |
cancercelllines; CVCL_D621
|
Encyclopedic resources |
Wikidata; Q54954499
|
Entry history |
Entry creation | 22-Oct-2012 |
Last entry update | 05-Oct-2023 |
Version number | 22 |
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