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Cellosaurus KB-C2 (CVCL_D600)

[Text version]
Cell line name KB-C2
Synonyms KBC2
Accession CVCL_D600
Resource Identification Initiative To cite this cell line use: KB-C2 (RRID:CVCL_D600)
Comments Problematic cell line: Contaminated. Ancestral cell line (KB) has been shown to be a HeLa derivative.
Population: African American.
Selected for resistance to: ChEBI; CHEBI:23359; Colchicine.
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
Disease Human papillomavirus-related cervical adenocarcinoma (NCIt: C27677)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1D80 (KB-C1.5)
CVCL_1D81 (KB-C2.5)
Sex of cell Female
Age at sampling 30Y6M
Category Cancer cell line

PubMed=3857583; DOI=10.1073/pnas.82.8.2330
Richert N., Akiyama S.-i., Shen D.-W., Gottesman M.M., Pastan I.
Multiply drug-resistant human KB carcinoma cells have decreased amounts of a 75-kDa and a 72-kDa glycoprotein.
Proc. Natl. Acad. Sci. U.S.A. 82:2330-2333(1985)

PubMed=3711108; DOI=10.1016/S0021-9258(19)57466-X
Shen D.-W., Cardarelli C., Hwang J., Cornwell M., Richert N., Ishii S., Pastan I., Gottesman M.M.
Multiple drug-resistant human KB carcinoma cells independently selected for high-level resistance to colchicine, adriamycin, or vinblastine show changes in expression of specific proteins.
J. Biol. Chem. 261:7762-7770(1986)

PubMed=11509122; DOI=10.1111/j.1349-7006.2001.tb01177.x
Aoki S., Chen Z.-S., Higasiyama K., Setiawan A., Akiyama S.-i., Kobayashi M.
Reversing effect of agosterol A, a spongean sterol acetate, on multidrug resistance in human carcinoma cells.
Jpn. J. Cancer Res. 92:886-895(2001)

Anatomy/cell type resources BTO; BTO:0005215
Encyclopedic resources Wikidata; Q54899550
Entry history
Entry creation22-Oct-2012
Last entry update05-Oct-2023
Version number16