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Cellosaurus KB-C2 (CVCL_D600)

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Cell line name KB-C2
Synonyms KBC2
Accession CVCL_D600
Resource Identification Initiative To cite this cell line use: KB-C2 (RRID:CVCL_D600)
Comments Problematic cell line: Contaminated. Ancestral cell line (KB) has been shown to be a HeLa derivative.
Population: African American.
Selected for resistance to: ChEBI; CHEBI_23359; Colchicine.
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Transformant: ChEBI; CHEBI_23994; Ethyl methanesulfonate (Methylsulfonic acid ethyl ester; MSEE).
Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
Sequence variations
  • Mutation; HGNC; HGNC:40; ABCB1; Simple; p.Gly185Val (c.554_555GA>TT); Zygosity=Unspecified (from parent cell line).
Disease Human papillomavirus-related endocervical adenocarcinoma (NCIt: C27677)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1D80 (KB-C1.5)
Children:
CVCL_1D81 (KB-C2.5)
Sex of cell Female
Age at sampling 30Y6M
Category Cancer cell line
Publications

PubMed=3857583; DOI=10.1073/pnas.82.8.2330; PMCID=PMC397551
Nancy Richert, Shin-ichi Akiyama, Ding-Wu Shen, Michael Marc Gottesman, Ira Pastan;
Multiply drug-resistant human KB carcinoma cells have decreased amounts of a 75-kDa and a 72-kDa glycoprotein.
Proc. Natl. Acad. Sci. U.S.A. 82:2330-2333(1985)

PubMed=3711108; DOI=10.1016/S0021-9258(19)57466-X
Ding-Wu Shen, Carol O. Cardarelli, Jaulang Hwang, Marilyn Cornwell, Nancy Richert, Shunsuke Ishii, Ira Pastan, Michael Marc Gottesman;
Multiple drug-resistant human KB carcinoma cells independently selected for high-level resistance to colchicine, adriamycin, or vinblastine show changes in expression of specific proteins.
J. Biol. Chem. 261:7762-7770(1986)

PubMed=11509122; DOI=10.1111/j.1349-7006.2001.tb01177.x; PMCID=PMC5926837
Shunji Aoki, Zhe-Sheng Chen, Kimihiko Higasiyama, Andi Setiawan, Shin-ichi Akiyama, Motomasa Kobayashi;
Reversing effect of agosterol A, a spongean sterol acetate, on multidrug resistance in human carcinoma cells.
Jpn. J. Cancer Res. 92:886-895(2001)

Cross-references
Anatomy/cell type resources BTO; BTO_0005215
Encyclopedic resources Wikidata; Q54899550
Entry history
Entry creation22-Oct-2012
Last entry update14-Aug-2025
Version number19