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Cellosaurus BJ SiPS-D TH-TdTomato DJ1 HOM KO (CVCL_D5YE)

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Cell line name BJ SiPS-D TH-TdTomato DJ1 HOM KO
Accession CVCL_D5YE
Resource Identification Initiative To cite this cell line use: BJ SiPS-D TH-TdTomato DJ1 HOM KO (RRID:CVCL_D5YE)
Comments Population: Caucasian.
Characteristics: Fluorescent (tdTomato) reporter cell line for TH expression. Using CRISPR/Cas9 a P2A-tdTomato construct was introduced in the C-terminal end of TH (from parent cell line).
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:16369; PARK7.
Genetic integration: Method=CRISPR/Cas9; Gene=FPbase; PGG5S; tdTomato (Note=Bright red fluorescent protein derived from drFP583 (DsRed)).
Derived from site: In situ; Foreskin, skin; UBERON=UBERON_0001471.
Cell type: Fibroblast of foreskin; CL=CL_1001608.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_C8FN (BJ SiPS-D TH-TdTomato)
Sex of cell Male
Age at sampling <1M
Category Induced pluripotent stem cell
Publications

PubMed=38200091; DOI=10.1038/s41467-024-44732-2; PMCID=PMC10781970
Gustavo Morrone Parfitt, Elena Coccia, Camille Goldman, Kristen Whitney, Ricardo Reyes, Lily Sarrafha, Ki Hong Nam, Soha Sohail, Drew R. Jones, John Fonda Crary, Alban Ordureau ...Show all 13 authors... , Joel W. Blanchard, Tim Ahfeldt; Show fewer authors
Disruption of lysosomal proteolysis in astrocytes facilitates midbrain organoid proteostasis failure in an early-onset Parkinson's disease model.
Nat. Commun. 15:447.1-447.17(2024)

Cross-references
Encyclopedic resources Wikidata; Q127380340
Entry history
Entry creation02-May-2024
Last entry update19-Dec-2024
Version number3