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Cellosaurus (CVCL_D5W4)

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Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: MD Anderson Cell Lines Project.
Part of: NCI RAS program mutant KRAS cell line panel.
Population: Caucasian.
Doubling time: ~25-40 hours (DSMZ=ACC-179).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Metabolomics.
Omics: Phenotyping; CRISPR screening.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Pancreas; UBERON=UBERON_0001264.
Sequence variations
  • Mutation; HGNC; HGNC:3373; EP300; Simple; p.Ser1650Tyr (c.4949C>A); Zygosity=Heterozygous (PubMed=10700188; Cosmic-CLP=1298526; DepMap=ACH-000599).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012583; Zygosity=Heterozygous (Cosmic-CLP=1298526; DepMap=ACH-000599).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Cys176Ser (c.526T>A); ClinVar=VCV000376570; Zygosity=Homozygous (PubMed=8194712; PubMed=10700188; Cosmic-CLP=1298526; DepMap=ACH-000599).
HLA typing Source: PubMed=26589293
Class I
HLA-AA*02:01,02:01
HLA-BB*51:01,51:01
HLA-CC*15:02,15:02
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0.21
East Asian, North1.73
East Asian, South0
South Asian0
European, North62.61
European, South35.45
Disease Pancreatic adenocarcinoma (NCIt: C8294)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 44Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=1298526; DSMZ=ACC-179; PubMed=25877200

Markers:
AmelogeninX
CSF1PO10,11
D2S133820
D3S135816,18
D5S81811,12
D7S8208,10
D8S117913
D13S31711,12
D16S5399,11
D18S5115
D19S43312,14
D21S1130
FGA23
Penta D11
Penta E12,15
TH019.3
TPOX8
vWA18

Run an STR similarity search on this cell line
Web pages Info; MCLP; -; https://tcpaportal.org/mclp/
Publications









passages.
Gaoxiong Yi Xue Ke Xue Za Zhi 10:170-176(1994)


John C. Schimenti;
Chromosomal deletion complexes in mice by radiation of embryonic stem cells.
Nat. Genet. 15:285-288(1997)


Estela E. Medrano;
SKI activates Wnt/beta-catenin signaling in human melanoma.
Cancer Res. 63:6626-6634(2003)


Isabelle Coupier, Celine Baldeyron, Alexandra Rousseau, Veronique Mosseri, Sabine Pages-Berhouet, Virginie Caux-Moncoutier, Dora Papadopoulo, Dominique Stoppa-Lyonnet;
Fidelity of DNA double-strand break repair in heterozygous cell lines harbouring BRCA1 missense mutations.
Oncogene 23:914-919(2004)



the inhibitor of apoptosis protein (IAP) family in human neoplasia.
Thesis MD (2005); Heinrich-Heine-Universitat Dusseldorf; Dusseldorf; Germany




Nat. Biotechnol. 26:1269-1275(2008)



Characterisation of a novel cell line (CSQT-2) with high metastatic activity derived from portal vein tumour thrombus of hepatocellular carcinoma.
Br. J. Cancer 102:1618-1626(2010)



switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K.
Cancer Cell 18:683-695(2010)


Julie Adam, Ann Hedley, Gabriela Kalna, Ian Philip Mark Tomlinson, Patrick John Pollard, David George Watson, Ralph J. DeBerardinis, Tomer Shlomi, Eytan Ruppin, Eyal Gottlieb;
Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase.
Nature 477:225-228(2011)


Stephen M. Hewitt, Lars Zender, Veena Kapoor, Dean W. Felsher, Michael Peter Manns, Firouzeh Korangy, Tim F. Greten;
Regulation of accumulation and function of myeloid derived suppressor cells in different murine models of hepatocellular carcinoma.
J. Hepatol. 59:1007-1013(2013)


Pedro G. Ferreira, Matthias Barann, Thomas Wieland, Liliana Greger, Maarten van Iterson, Jonas Carlsson Almlof, Paolo Ribeca, Irina Pulyakhina, Daniela Esser, Thomas Giger, Andrew Tikhonov ...Show all 48 authors... , Marc Sultan, Gabrielle Bertier, Daniel Geoffrey MacArthur, Monkol Lek, Esther Lizano, Henk P.J. Buermans, Ismael Padioleau, Thomas Schwarzmayr, Olof Karlberg, Halit Ongen, Helena Kilpinen, Sergi Beltran, Marta Gut, Katja Kahlem, Vyacheslav Amstislavskiy, Oliver Stegle, Matti Pirinen, Stephen B. Montgomery, Peter Donnelly, Mark Ian McCarthy, Paul Flicek, Tim-Matthias Strom, Hans Lehrach, Stefan Schreiber, Ralf Sudbrak, Angel Carracedo, Stylianos E. Antonarakis, Robert Hasler, Ann-Christine Syvanen, Gert-Jan B. van Ommen, Alvis Brazma, Thomas Meitinger, Philip Rosenstiel, Roderic Guigo, Ivo G. Gut, Xavier Estivill, Emmanouil Theophilos Dermitzakis; Show fewer authors
Geuvadis Consortium
Transcriptome and genome sequencing uncovers functional variation in humans.
Nature 501:506-511(2013)



electron-transfer/higher-energy collision dissociation (EThcD).
Proc. Natl. Acad. Sci. U.S.A. 111:4507-4512(2014)


Hangnoh Lee, Charles Joel McManus, Dong-Yeon Cho, Matthew Eaton, Fioranna Renda, Maria Patrizia Somma, Lucy Cherbas, Gemma May, Sara Powell, Da-Yu Zhang, Li-Jun Zhan ...Show all 20 authors... , Alissa Resch, Justen Andrews, Susan E. Celniker, Peter Cherbas, Teresa Maria Przytycka, Maurizio Gatti, Brian Oliver, Brenton R. Graveley, David M. MacAlpine; Show fewer authors
DNA copy number evolution in Drosophila cell lines.
Genome Biol. 15:R70.1-R70.20(2014)


Yasuhiro Takashima, Ge Guo, Remco Loos, Jennifer Nichols, Gabriella Ficz, Felix Krueger, David Oxley, Fatima Santos, James Clarke, William Mansfield, Wolf Reik ...Show all 13 authors... , Paul Bertone, Austin Gerard Smith; Show fewer authors
Resetting transcription factor control circuitry toward ground-state pluripotency in human.
Cell 158:1254-1269(2014)


Thomas Graf;
Erratum to 'C/EBPalpha induces highly efficient macrophage transdifferentiation of B lymphoma and leukemia cell lines and impairs their tumorigenicity'.
Cell Rep. 19:1281-1281(2017)



literature.
Cancer Res. 77:2784-2788(2017)


Ruta Meleckyte, Yasin Memari, Nathalie Moens, Filipa Soares, Alice Mann, Ian Streeter, Chukwuma A. Agu, Alex Alderton, Rachel Nelson, Sarah Harper, Minal J. Patel ...Show all 27 authors... , Alistair White, Sharad R. Patel, Laura Clarke, Reena Halai, Christopher Michael Kirton, Anja Kolb-Kokocinski, Philip L. Beales, Ewan Birney, Davide Danovi, Angus Iain Lamond, Willem Hendrik Ouwehand, Ludovic Vallier, Fiona Mary Watt, Richard Michael Durbin, Oliver Stegle, Daniel J. Gaffney; Show fewer authors
Common genetic variation drives molecular heterogeneity in human iPSCs.
Nature 546:370-375(2017)


Tetsuhiro Kikuchi, Asuka Morizane, Daisuke Doi, Hiroaki Magotani, Hirotaka Onoe, Takuya Hayashi, Hiroshi Mizuma, Sayuki Takara, Ryosuke Takahashi, Haruhisa Inoue, Satoshi Morita ...Show all 16 authors... , Michio Yamamoto, Keisuke Okita, Masato Nakagawa, Malin Parmar, Jun Takahashi; Show fewer authors
Human iPS cell-derived dopaminergic neurons function in a primate Parkinson's disease model.
Nature 548:592-596(2017)




Cancer Cell 33:386-400.e5(2018)

Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number37