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Cellosaurus (CVCL_D5IN)

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Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: NCI RAS program mutant KRAS cell line panel.
Population: Japanese and Korean.
Doubling time: 21.1 hours (Note=Lot 061891), ~25 hours (Note=Lot 10092014) (JCRB=JCRB0080).
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Cys (c.34G>T); ClinVar=VCV000012578; Zygosity=Heterozygous (DepMap=ACH-000444).
HLA typing Source: PubMed=26589293
Class I
HLA-AA*24:02,24:02
HLA-BB*52:01,54:01
HLA-CC*01:02,01:02
Class II
HLA-DQDQA1*05:02,05:02
HLA-DRDRB1*03:19,15:02
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.25
Native American0
East Asian, North84.63
East Asian, South13.5
South Asian0
European, North0
European, South1.62
Disease Lung giant cell carcinoma (NCIt: C4452)
Species of origin Canis lupus familiaris (Dog) (Canis familiaris) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 63Y
Category Cancer cell line
STR profile Source(s): JCRB=JCRB0080; RCB=RCB1900; TKG=TKG 0495

Markers:
AmelogeninX
CSF1PO10,15
D13S31710,11
D16S5399
D5S81812
D7S82011
TH019
TPOX11
vWA18

Run an STR similarity search on this cell line
Publications






line.
Jibi To Rinsho 34 Suppl. 1:329-333(1988)



alveologenic carcinoma.
Mol. Carcinog. 3:387-392(1990)


Isabell A. Sesterhenn, David Gwin McLeod, Johng Sik Rhim;
A novel human cancer culture model for the study of prostate cancer.
Oncogene 20:8036-8041(2001)



nude-beige mice.
Cancer Res. 64 Suppl. 7:1179-1180(2004)


Julie Adam, Ann Hedley, Gabriela Kalna, Ian Philip Mark Tomlinson, Patrick John Pollard, David George Watson, Ralph J. DeBerardinis, Tomer Shlomi, Eytan Ruppin, Eyal Gottlieb;
Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase.
Nature 477:225-228(2011)


Hangnoh Lee, Charles Joel McManus, Dong-Yeon Cho, Matthew Eaton, Fioranna Renda, Maria Patrizia Somma, Lucy Cherbas, Gemma May, Sara Powell, Da-Yu Zhang, Li-Jun Zhan ...Show all 20 authors... , Alissa Resch, Justen Andrews, Susan E. Celniker, Peter Cherbas, Teresa Maria Przytycka, Maurizio Gatti, Brian Oliver, Brenton R. Graveley, David M. MacAlpine; Show fewer authors
DNA copy number evolution in Drosophila cell lines.
Genome Biol. 15:R70.1-R70.20(2014)



literature.
Cancer Res. 77:2784-2788(2017)


Tetsuhiro Kikuchi, Asuka Morizane, Daisuke Doi, Hiroaki Magotani, Hirotaka Onoe, Takuya Hayashi, Hiroshi Mizuma, Sayuki Takara, Ryosuke Takahashi, Haruhisa Inoue, Satoshi Morita ...Show all 16 authors... , Michio Yamamoto, Keisuke Okita, Masato Nakagawa, Malin Parmar, Jun Takahashi; Show fewer authors
Human iPS cell-derived dopaminergic neurons function in a primate Parkinson's disease model.
Nature 548:592-596(2017)


Maryam Alowaysi, Mohammad Al-Shehri, Amani Badkok, Hanouf Attas, Doaa Aboalola, Moayad Baadhaim, Hajar AlZahrani, Mustafa Daghestani, Asima Zia, Khalid AlGhamdi, Asayil AlGhamdi ...Show all 15 authors... , Samer Zakri, Sihem Aouabdi, Jesper Tegner, Khaled N. Alsayegh; Show fewer authors
Generation of iPSC lines (KAIMRCi003A, KAIMRCi003B) from a Saudi patient with Dravet syndrome carrying homozygous mutation in the CPLX1 gene and heterozygous mutation in SCN9A.
Hum. Cell 37:502-510(2024)


Damian Smedley, Lorenz P. Studer, Wei Sun, Dusica Vidovic, Thomas Vierbuchen, Brian S. White, Ka Yee Yeung, Feng Yue, Ting Zhou;
MorPhiC Consortium
MorPhiC Consortium: towards functional characterization of all human genes.
Nature 638:351-359(2025)

Cross-references
Cell line collections (Providers) JCRB; JCRB0080
RCB; RCB1900
TKG; TKG 0495
Cell line databases/resources cancercelllines; CVCL_3015
Cell_Model_Passport; SIDM00546
DepMap; ACH-000444
Biological sample resources BioSample; SAMN03471066
BioSample; SAMN10987825
Chemistry resources ChEMBL-Cells; CHEMBL3308600
ChEMBL-Targets; CHEMBL614651
PubChem_Cell_line; CVCL_3015
Encyclopedic resources Wikidata; Q54903211
Gene expression databases GEO; GSM887283
GEO; GSM888358
Polymorphism and mutation databases Cosmic; 801578
Cosmic; 808503
Cosmic; 844828
Cosmic; 876174
Cosmic; 946068
Cosmic; 1048224
Cosmic; 1571756
Cosmic; 1656907
Cosmic; 2125270
IARC_TP53; 30114
LiGeA; CCLE_430
Progenetix; CVCL_3015
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number32