• Mutation; HGNC; HGNC:5173; HRAS; Simple; p.Gly13Arg (c.37G>C); ClinVar=VCV000035554; Zygosity=Unspecified (PubMed=2654810).
  
• Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gly279Glu (c.836G>A); ClinVar=VCV000419454; Zygosity=Unspecified (PubMed=1570156).
  

PubMed=2654810
Keiko Tadokoro, Masayoshi Ueda, Tomoko Ohshima, Keijiro Fujita, Koichi Rikimaru, Nobuyoshi Takahashi, Shoji Enomoto, Nobuo Tsuchida;
Activation of oncogenes in human oral cancer cells: a novel codon 13 mutation of c-H-ras-1 and concurrent amplifications of c-erbB-1 and c-myc.
Oncogene 4:499-505(1989)

PubMed=2228902; DOI=10.1007/BF02624609
Koichi Rikimaru, Hitomi Toda, Noriko Tachikawa, Nobuyuki Kamata, Shoji Enomoto;
Growth of the malignant and nonmalignant human squamous cells in a protein-free defined medium.
In Vitro Cell. Dev. Biol. 26:849-856(1990)

PubMed=1570156
Eiki Sakai, Nobuo Tsuchida;
Most human squamous cell carcinomas in the oral cavity contain mutated p53 tumor-suppressor genes.
Oncogene 7:927-933(1992)

PubMed=10069537; DOI=10.1111/j.1600-0714.1999.tb02006.x
Toshiaki Hoteiya, Eiji Hayashi, Kazuhito Satomura, Nobuyuki Kamata, Masaru Nagayama;
Expression of E-cadherin in oral cancer cell lines and its relationship to invasiveness in SCID mice in vivo.
J. Oral Pathol. Med. 28:107-111(1999)

PubMed=12632084; DOI=10.3892/ijo.22.4.891
Kazuhiro Yokoyama, Nobuyuki Kamata, Ryoichi Fujimoto, Satoshi Tsutsumi, Mayumi Tomonari, Masayuki Taki, Hiroyoshi Hosokawa, Masaru Nagayama;
Increased invasion and matrix metalloproteinase-2 expression by Snail-induced mesenchymal transition in squamous cell carcinomas.
Int. J. Oncol. 22:891-898(2003)

PubMed=17052259; DOI=10.1111/j.1349-7006.2006.00343.x; PMCID=PMC11160012
Ken-ichi Kozaki, Issei Imoto, Atiphan Pimkhaokham, Shogo Hasegawa, Hitoshi Tsuda, Ken Omura, Johji Inazawa;
PIK3CA mutation is an oncogenic aberration at advanced stages of oral squamous cell carcinoma.
Cancer Sci. 97:1351-1358(2006)

PubMed=17599052; DOI=10.1038/sj.onc.1210589
Emina Suzuki, Issei Imoto, Atiphan Pimkhaokham, Takayuki Nakagawa, Nobuyuki Kamata, Ken-ichi Kozaki, Teruo Amagasa, Johji Inazawa;
PRTFDC1, a possible tumor-suppressor gene, is frequently silenced in oral squamous-cell carcinomas by aberrant promoter hypermethylation.
Oncogene 26:7921-7932(2007)

PubMed=18097548; DOI=10.3892/ijo.32.1.101
Avaniyapuram Kannan Murugan, Nguyen Thi Hong, Yasuhisa Fukui, Arasambattu Kannan Munirajan, Nobuo Tsuchida;
Oncogenic mutations of the PIK3CA gene in head and neck squamous cell carcinomas.
Int. J. Oncol. 32:101-111(2008)