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Cellosaurus HEK293-NOD2 L1007fsinsC (CVCL_D4ZM)

[Text version]
Cell line name HEK293-NOD2 L1007fsinsC
Synonyms FLP-IN HEK 293-NOD2-L1007fsinsC; HEK293-NOD2(SNP13)
Accession CVCL_D4ZM
Resource Identification Initiative To cite this cell line use: HEK293-NOD2 L1007fsinsC (RRID:CVCL_D4ZM)
Comments Genetic integration: Method=Transfection; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:5331; NOD2 (Note=With p.Leu1007Profs*2).
Genetic integration: Method=Transfection; Gene=UniProtKB; P00722; Escherichia coli beta-galactosidase (lacZ).
Genetic integration: Method=Transfection; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Genetic integration: Method=Transfection; Gene=UniProtKB; P04483; Escherichia coli Tn10 tetR.
Genetic integration: Method=Transfection; Gene=UniProtKB; P17493; Streptoalloteichus hindustanus ble (BleoR).
Transformant: NCBI_TaxID; 28285; Human adenovirus C serotype 5.
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Fetal kidney; UBERON=UBERON_0002113.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_U427 (Flp-In-T-REx-293)
Sex of cell Female
Age at sampling Fetus
Category Transformed cell line
Publications

PubMed=16257953; DOI=10.1074/jbc.M505986200
Dieter Weichart, Johan Gobom, Sina Klopfleisch, Robert Hasler, Niklas Gustavsson, Susanne Billmann-Born, Hans Lehrach, Dirk Seegert, Stefan Schreiber, Philip Rosenstiel;
Analysis of NOD2-mediated proteome response to muramyl dipeptide in HEK293 cells.
J. Biol. Chem. 281:2380-2389(2006)

PubMed=21335489; DOI=10.4049/jimmunol.1000085
Susanne Billmann-Born, Andreas Till, Alexander Arlt, Simone Lipinski, Christian Sina, Anna Latiano, Vito Annese, Robert Hasler, Martin Kerick, Thomas Manke, Dirk Seegert ...Show all 17 authors... , Adedayo Hanidu, Heiner Schafer, David A. van Heel, Jun Li, Stefan Schreiber, Philip Rosenstiel; Show fewer authors
Genome-wide expression profiling identifies an impairment of negative feedback signals in the Crohn's disease-associated NOD2 variant L1007fsinsC.
J. Immunol. 186:4027-4038(2011)

Cross-references
Encyclopedic resources Wikidata; Q127381646
Gene expression databases GEO; GSM560858
GEO; GSM560859
GEO; GSM560860
GEO; GSM560867
GEO; GSM560868
GEO; GSM560869
GEO; GSM560876
GEO; GSM560877
GEO; GSM560878
Entry history
Entry creation02-May-2024
Last entry update14-Aug-2025
Version number5