Cellosaurus logo
expasy logo
Due to maintenance work, this service will be unavailable on Monday between 06:00 until 06:30 CEST. Apologies for the inconvenience.

Cellosaurus ACE2plusC3 (CVCL_D4Z5)

[Text version]
Cell line name ACE2plusC3
Synonyms ACE2plusC3-A549/ACE2/TMPRSS2
Accession CVCL_D4Z5
Resource Identification Initiative To cite this cell line use: ACE2plusC3 (RRID:CVCL_D4Z5)
Comments Group: SARS-CoV-2 research cell line.
Population: Caucasian.
Virology: Highly susceptible to infection by SARS coronavirus 2 (SARS-CoV-2) (COVID-19) (PubMed=35891350).
Doubling time: ~24-36 hours (ATCC=CRL-3560).
Transfected with: HGNC; 13557; ACE2.
Transfected with: HGNC; 11876; TMPRSS2.
Transfected with: UniProtKB; P13249; S.alboniger pac (PuroR).
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Ser (c.34G>A); ClinVar=VCV000012584; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0023 (A-549)
Sex of cell Male
Age at sampling 58Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-3560

Markers:
AmelogeninX
CSF1PO10,12
D5S81811
D7S8208,11
D13S31711
D16S53911,12
TH018,9.3
TPOX8,11
vWA14

Run an STR similarity search on this cell line
Publications

PubMed=35891350; DOI=10.3390/v14071369
Chang C.-W., Parsi K.M., Somasundaran M., Vanderleeden E., Liu P., Cruz J., Cousineau A., Finberg R.W., Kurt-Jones E.A.
A newly engineered A549 cell line expressing ACE2 and TMPRSS2 Is highly permissive to SARS-CoV-2, including the delta and omicron variants.
Viruses 14:1369.1-1369.14(2022)

Cross-references
Cell line collections (Providers) ATCC; CRL-3560
Entry history
Entry creation02-May-2024
Last entry update02-May-2024
Version number1