Cellosaurus cell line SKMEL28-SLC13A3-KO-c4 (CVCL

Cellosaurus SKMEL28-SLC13A3-KO-c4 (CVCL_D4WR)

Cross-references
Cell line name	SKMEL28-SLC13A3-KO-c4
Synonyms	CE05P5-H
Accession	CVCL_D4WR
Resource Identification Initiative	To cite this cell line use: SKMEL28-SLC13A3-KO-c4 (RRID:CVCL_D4WR)
Comments	Part of: Research Empowerment on Solute Carriers (RESOLUTE) KO cell line panel. Population: Caucasian. Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:14430; SLC13A3. Derived from site: In situ; Skin; UBERON=UBERON_0002097. Cell type: Melanocyte of skin; CL=CL_1000458.
Sequence variations	Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (from parent cell line). Mutation; HGNC; HGNC:1773; CDK4; Simple; p.Arg24Cys (c.70C>T); ClinVar=VCV000016928; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Pro753Ser (c.2257C>T); ClinVar=VCV000376081; Zygosity=Homozygous (from parent cell line). Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Thr167Ala (c.499A>G); ClinVar=VCV001686107; Zygosity=Homozygous (from parent cell line). Mutation; HGNC; HGNC:11730; TERT; Simple; c.-57A>C (c.161A>C) (A161C); ClinVar=VCV000242210; Zygosity=Unspecified; Note=In promoter (from parent cell line). Mutation; HGNC; HGNC:11998; TP53; Simple; p.Leu145Arg (c.434T>G); ClinVar=VCV001027110; Zygosity=Homozygous (from parent cell line).
Disease	Cutaneous melanoma (NCIt: C3510)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0526 (SK-MEL-28)
Sex of cell	Male
Age at sampling	51Y
Category	Cancer cell line
Web pages	Info; RESOLUTE; CE05P5-H; https://re-solute.eu/resources/reagents
Encyclopedic resources	Wikidata; Q127384309
Entry history
Entry creation	30-Jan-2024
Last entry update	10-Apr-2025
Version number	4