Cellosaurus cell line MDFSP-S1 (CVCL

Cellosaurus MDFSP-S1 (CVCL_D4A8)

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Cell line name

MDFSP-S1

Accession

CVCL_D4A8

Resource Identification Initiative

To cite this cell line use: MDFSP-S1 (RRID:CVCL_D4A8)

Comments

Population: Chinese.
Characteristics: Imatinib resistant (PubMed=37610680).
Doubling time: ~5 days (PubMed=37610680).
Omics: Genomics; Whole genome sequencing.
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Right gluteal muscle; UBERON=UBERON_0002000.

Sequence variations

Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=37610680).
Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (PubMed=37610680).
Gene fusion; HGNC; HGNC:2197; COL1A1 + HGNC; HGNC:8800; PDGFB; Name(s)=COL1A1-PDGFB (PubMed=37610680).

Disease

Dermatofibrosarcoma protuberans (NCIt: C4683)
Dermatofibrosarcoma protuberans (ORDO: Orphanet_31112)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Female

Age at sampling

47Y

Category

Cancer cell line

STR profile

Source(s): PubMed=37610680

Markers:

Amelogenin	X
CSF1PO	11,12
D1S1656	13,14
D2S441	10,14
D2S1338	19,24
D3S1358	15,16
D5S818	7,10
D7S820	8,12
D8S1179	10,13
D10S1248	13,14
D12S391	17,18
D13S317	10,13
D16S539	10,12
D18S51	13,17
D19S433	14,15.2
D21S11	27,32
D22S1045	15
FGA	21,24
Penta D	8,10
Penta E	11
TH01	7,9
TPOX	8
vWA	14,17

Publications

PubMed=37610680; DOI=10.1007/s13577-023-00974-8
Jason Yong-Sheng Chan, Elizabeth Chun-Yong Lee, Zhi-Mei Li, Jing-Yi Lee, Abner Herbert Lim, Eileen Poon;
Multi-omic profiling and real time ex vivo modelling of imatinib-resistant dermatofibrosarcoma protuberans with fibrosarcomatous transformation.
Hum. Cell 36:2228-2236(2023)

Cross-references

Encyclopedic resources

Wikidata; Q127382793

Entry history

Entry creation

30-Jan-2024

Last entry update

10-Apr-2025

Version number