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Cellosaurus 697-R (CVCL_D3Z6)

[Text version]
Cell line name 697-R
Synonyms 697R
Accession CVCL_D3Z6
Resource Identification Initiative To cite this cell line use: 697-R (RRID:CVCL_D3Z6)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:66484; Silvestrol.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Gene fusion; HGNC; 8632; PBX1 + HGNC; 11633; TCF3; Name(s)=TCF3-PBX1; E2A-PBX1 (from parent cell line).
Disease Childhood B acute lymphoblastic leukemia (NCIt: C9140)
B acute lymphoblastic leukemia with t(1;19)(q23;p13.3) E2A-PBX1 (TCF3-PBX1) (NCIt: C80347)
B-lymphoblastic leukemia/lymphoma with t(1;19)(q23;p13.3) (ORDO: Orphanet_585956)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0079 (697)
Sex of cell Male
Age at sampling 12Y
Category Cancer cell line
Publications

PubMed=21538216; DOI=10.1208/s12248-011-9276-7
Gupta S.V., Sass E.J., Davis M.E., Edwards R.B., Lozanski G., Heerema N.A., Lehman A., Zhang X.-L., Jarjoura D., Byrd J.C., Pan L., Chan K.K., Kinghorn A.D., Phelps M.A., Grever M.R., Lucas D.M.
Resistance to the translation initiation inhibitor silvestrol is mediated by ABCB1/P-glycoprotein overexpression in acute lymphoblastic leukemia cells.
AAPS J. 13:357-364(2011)

Entry history
Entry creation30-Jan-2024
Last entry update30-Jan-2024
Version number1