Cellosaurus cell line NCC-PMP2-C1 (CVCL

Cellosaurus NCC-PMP2-C1 (CVCL_D3Z1)

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Cell line name

NCC-PMP2-C1

Accession

CVCL_D3Z1

Resource Identification Initiative

To cite this cell line use: NCC-PMP2-C1 (RRID:CVCL_D3Z1)

Comments

Population: Japanese.
Senescence: It is possible that this cell line is not immortal and has a finite life span (personal communication of Kondo, Tadashi).
Doubling time: ~97 hours (PubMed=38143259).
Omics: Phenotyping; Drug screening.
Omics: Variations; SNP array analysis.
Derived from site: Metastatic; Peritoneal cavity; UBERON=UBERON_0001179.

Sequence variations

Gene deletion; HGNC; HGNC:6770; SMAD4; Zygosity=Homozygous (PubMed=38143259).
Gene deletion; HGNC; HGNC:11389; STK11; Zygosity=Homozygous (PubMed=38143259).
Mutation; HGNC; HGNC:427; ALK; Simple; p.Thr122Met (c.365C>T); ClinVar=VCV000538194; Zygosity=Unspecified (PubMed=38143259).
Mutation; HGNC; HGNC:18037; ARID2; Simple; p.Gln25Ter (c.73C>T); Zygosity=Unspecified (PubMed=38143259).
Mutation; HGNC; HGNC:10261; ROS1; Simple; p.Pro151Leu (c.452C>T); Zygosity=Unspecified (PubMed=38143259).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.Cys141Trp (c.423C>G); ClinVar=VCV000376564; Zygosity=Unspecified (PubMed=38143259).

Disease

High grade mucinous carcinoma peritonei with signet ring cells (NCIt: C203949)
Pseudomyxoma peritonei (ORDO: Orphanet_26790)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Male

Age at sampling

57Y

Category

Cancer cell line

STR profile

Source(s): PubMed=38143259

Markers:

Amelogenin	X
CSF1PO	9,10,12
D5S818	9,12
D7S820	10,11
D13S317	8
D16S539	9,10
D21S11	31,32.2
TH01	9
TPOX	8,12
vWA	14,17

Publications

PubMed=38143259; DOI=10.1007/s13577-023-01015-0
Rei Noguchi, Yuki Yoshimatsu, Yooksil Sin, Takuya Ono, Ryuto Tsuchiya, Hiroshi Yoshida, Tohru Kiyono, Yutaka Yonemura, Tadashi Kondo;
Establishment and characterization of NCC-PMP2-C1: a novel patient-derived cell line of pseudomyxoma peritonei with signet ring cells.
Hum. Cell 37:511-522(2024)

Cross-references

Encyclopedic resources

Wikidata; Q127382935

Entry history

Entry creation

30-Jan-2024

Last entry update

10-Apr-2025

Version number