Cellosaurus cell line Zt/g4 (CVCL

Cross-references
Cell line name	Zt/g4
Accession	CVCL_D3UL
Resource Identification Initiative	To cite this cell line use: Zt/g4 (RRID:CVCL_D3UL)
Comments	Biotechnology: The monoclonal antibody produced by this hybridoma was used to prepare a humanized monomethyl auristatin E conjugated (Zt/g4-MMAE) therapeutic antibody whcih is evaluated for the treatment of pancreatic cancer. Monoclonal antibody isotype: IgG1, lambda. Monoclonal antibody target: UniProtKB; Q04912; Human MST1R/CD136.
Species of origin	Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Hierarchy	Parent: CVCL_2199 (Sp2/0-Ag14)
Category	Hybridoma
Publications	PubMed=16880737; DOI=10.4161/cbt.5.9.3073 Hang-Ping Yao, Yu-Lan Luo, Lei Feng, Lin-Fang Cheng, Yi Lu, Wei Li, Ming-Hai Wang; Agonistic monoclonal antibodies potentiate tumorigenic and invasive activities of splicing variant of the RON receptor tyrosine kinase. Cancer Biol. Ther. 5:1179-1186(2006) PubMed=21749705; DOI=10.1186/1476-4598-10-82; PMCID=PMC3142532 Hang-Ping Yao, Yong-Qing Zhou, Qi Ma, Sunny Guin, Snehal S. Padhye, Rui-Wen Zhang, Ming-Hai Wang; The monoclonal antibody Zt/f2 targeting RON receptor tyrosine kinase as potential therapeutics against tumor growth-mediated by colon cancer cells. Mol. Cancer 10:82.1-82.12(2011)
Encyclopedic resources	Wikidata; Q127384796
Entry history
Entry creation	30-Jan-2024
Last entry update	10-Sep-2024
Version number	2