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Cellosaurus iBMK BIM-/- A (CVCL_D3KE)

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Cell line name iBMK BIM-/- A
Synonyms BIM-/- A; immortalized Baby Mouse Kidney epithelial cell line BIM-/- A
Accession CVCL_D3KE
Resource Identification Initiative To cite this cell line use: iBMK BIM-/- A (RRID:CVCL_D3KE)
Comments Knockout cell: Method=KO mouse; MGI; MGI:1197519; Bcl2l11.
Genetic integration: Method=Transfection; Gene=MGI; MGI:98834; Trp53 (Note=With p.Leu14_Lys302del = p53DD).
Genetic integration: Method=Transfection; Gene=UniProtKB; P03255; Human adenovirus C serotype 5 E1A protein.
Transformant: NCBI_TaxID; 28285; Human adenovirus C serotype 5 (Note=E1A).
Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
Cell type: Epithelial cell of kidney; CL=CL_0002518.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C57BL/6.
Hierarchy Children:
CVCL_D3KK (iBMK BIM-/- A.3.1-C1)CVCL_D3KL (iBMK BIM-/- A.3.1-C2)CVCL_D3KM (iBMK BIM-/- A.Hras-A)
CVCL_D3KN (iBMK BIM-/- A.Hras-B)CVCL_D3KP (iBMK BIM-/- A.Hras-C)CVCL_D3KQ (iBMK BIM-/- A.Raf-A)
CVCL_D3KR (iBMK BIM-/- A.Raf-B)CVCL_D3KS (iBMK BIM-/- A.Raf-C)
Sex of cell Sex unspecified
Age at sampling <2D
Category Transformed cell line
Publications

PubMed=15766661; DOI=10.1016/j.ccr.2005.02.008
Ting-Ting Tan, Kurt Degenhardt, Deirdre A. Nelson, Brian Beaudoin, Wilberto Nieves-Neira, Philippe Bouillet, Andreas Villunger, Jerry McKee Adams, Eileen White;
Key roles of BIM-driven apoptosis in epithelial tumors and rational chemotherapy.
Cancer Cell 7:227-238(2005)

PubMed=18603117; DOI=10.1016/S0076-6879(08)01605-4
Robin Mathew, Kurt Degenhardt, Liti Haramaty, Cristina M. Karp, Eileen White;
Immortalized mouse epithelial cell models to study the role of apoptosis in cancer.
Methods Enzymol. 446:77-106(2008)

Cross-references
Encyclopedic resources Wikidata; Q127382140
Entry history
Entry creation30-Jan-2024
Last entry update14-Aug-2025
Version number4