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Cellosaurus iBMK Atg5+/- 5.1B2 (CVCL_D3IS)

[Text version]
Cell line name iBMK Atg5+/- 5.1B2
Synonyms 5.1B2
Accession CVCL_D3IS
Resource Identification Initiative To cite this cell line use: iBMK Atg5+/- 5.1B2 (RRID:CVCL_D3IS)
Comments Knockout cell: Method=KO mouse; MGI; MGI:1277186; Atg5 (Note=1 of 2 alleles).
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:990; BCL2.
Genetic integration: Method=Transfection; Gene=MGI; MGI:98834; Trp53 (Note=With p.Leu14_Lys302del = p53DD).
Genetic integration: Method=Transfection; Gene=UniProtKB; P03255; Human adenovirus C serotype 5 E1A protein.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Transformant: NCBI_TaxID; 28285; Human adenovirus C serotype 5 (Note=E1A).
Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
Cell type: Epithelial cell of kidney; CL=CL_0002518.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C57BL/6.
Hierarchy Parent: CVCL_D3I9 (iBMK Atg5+/- 5.1)
Sex of cell Sex unspecified
Age at sampling <2D
Category Transformed cell line
Publications

PubMed=17510285; DOI=10.1101/gad.1545107; PMCID=PMC1877749
Robin Mathew, Sameera Kongara, Brian Beaudoin, Cristina M. Karp, Kevin Bray, Kurt Degenhardt, Guang-Hua Chen, Sheng-Kan Jin, Eileen White;
Autophagy suppresses tumor progression by limiting chromosomal instability.
Genes Dev. 21:1367-1381(2007)

PubMed=18603117; DOI=10.1016/S0076-6879(08)01605-4
Robin Mathew, Kurt Degenhardt, Liti Haramaty, Cristina M. Karp, Eileen White;
Immortalized mouse epithelial cell models to study the role of apoptosis in cancer.
Methods Enzymol. 446:77-106(2008)

Cross-references
Encyclopedic resources Wikidata; Q127382104
Entry history
Entry creation30-Jan-2024
Last entry update14-Aug-2025
Version number5