Cellosaurus cell line SK-MEL-257 (CVCL

Cross-references
Cell line name	SK-MEL-257
Accession	CVCL_D3F1
Resource Identification Initiative	To cite this cell line use: SK-MEL-257 (RRID:CVCL_D3F1)
Comments	From: Memorial Sloan Kettering Cancer Center; New York; USA.
Sequence variations	Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=9598804). Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (PubMed=9598804). Mutation; HGNC; HGNC:1773; CDK4; Simple; p.Arg24Cys (c.70C>T); ClinVar=VCV000016928; Zygosity=Heterozygous (PubMed=9598804).
Disease	Melanoma (NCIt: C3224)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Sex unspecified
Age at sampling	Age unspecified
Category	Cancer cell line
Publications	PubMed=9598804; DOI=10.1002/(SICI)1098-2264(199806)22:2<157::AID-GCC11>3.0.CO;2-N Graeme J. Walker, Jose F. Flores, J. Michael Glendening, Amy Hsiu-Ti Lin, Isabel D.C. Markl, Jane W. Fountain; Virtually 100% of melanoma cell lines harbor alterations at the DNA level within CDKN2A, CDKN2B, or one of their downstream targets. Genes Chromosomes Cancer 22:157-163(1998)
Encyclopedic resources	Wikidata; Q127384299
Entry history
Entry creation	30-Jan-2024
Last entry update	14-Aug-2025
Version number	4