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Cellosaurus U-2 OS/IDH2-R172M (CVCL_D3DK)

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Cell line name U-2 OS/IDH2-R172M
Accession CVCL_D3DK
Resource Identification Initiative To cite this cell line use: U-2 OS/IDH2-R172M (RRID:CVCL_D3DK)
Comments Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:5383; IDH2 (Note=With p.Arg172Met).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: In situ; Bone, tibia; UBERON=UBERON_0000979.
Sequence variations
  • Mutation; HGNC; HGNC:9277; PPM1D; Simple; p.Arg458Ter (c.1372C>T); ClinVar=VCV002445214; Zygosity=Heterozygous (from parent cell line).
Disease Osteosarcoma (NCIt: C9145)
Osteosarcoma (ORDO: Orphanet_668)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0042 (U2OS)
Sex of cell Female
Age at sampling 15Y
Category Cancer cell line
Publications

PubMed=25753205; DOI=10.1016/j.bbrc.2015.02.162
Xing Liu, Satoshi Ogasawara, Mika Kato Kaneko, Hiroharu Oki, Yasukazu Hozumi, Kaoru Goto, Michiaki Takagi, Yukinari Kato;
A novel monoclonal antibody SMab-2 recognizes endogenous IDH2-R172S of chondrosarcoma.
Biochem. Biophys. Res. Commun. 459:636-642(2015)

Cross-references
Encyclopedic resources Wikidata; Q127384427
Entry history
Entry creation30-Jan-2024
Last entry update14-Aug-2025
Version number4