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Cellosaurus K562-IMR (CVCL_D201)

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Cell line name K562-IMR
Synonyms K562-IM-R; K562 IMR; K562/IMR
Accession CVCL_D201
Resource Identification Initiative To cite this cell line use: K562-IMR (RRID:CVCL_D201)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_45783; Imatinib (Gleevec; STI571).
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln136fs*13 (c.406_407insC); Zygosity=Homozygous (from parent cell line).
Disease Blast phase chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C9110)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0004 (K-562)
Sex of cell Female
Age at sampling 53Y
Category Cancer cell line
Publications

PubMed=18829496; DOI=10.1158/1078-0432.CCR-08-0461
Seiichi Okabe, Tetsuzo Tauchi, Kazuma Ohyashiki;
Characteristics of dasatinib- and imatinib-resistant chronic myelogenous leukemia cells.
Clin. Cancer Res. 14:6181-6186(2008)

Cross-references
Encyclopedic resources Wikidata; Q54899392
Entry history
Entry creation22-Oct-2012
Last entry update19-Dec-2024
Version number21