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Cellosaurus D492 (CVCL_D1HJ)

[Text version]
Cell line name D492
Accession CVCL_D1HJ
Resource Identification Initiative To cite this cell line use: D492 (RRID:CVCL_D1HJ)
Comments Characteristics: Has a basal-like phenotype and has stem cell properties as demonstrated by its ability to differentiate into luminal- and myoepithelial cells (PubMed=21915264; PubMed=30684066).
Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Derived from site: In situ; Breast, epithelium; UBERON=UBERON_0008367.
Cell type: Luminal epithelial cell; CL=CL_0002326.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_D1HK (D492M)
Sex of cell Female
Age at sampling Adult
Category Transformed cell line
Publications

PubMed=11914275; DOI=10.1101/gad.952602; PMCID=PMC155359
Thorarinn Gudjonsson, Rene Villadsen, Helga Lind Nielsen, Lone Ronnov-Jessen, Mina J. Bissell, Ole William Petersen;
Isolation, immortalization, and characterization of a human breast epithelial cell line with stem cell properties.
Genes Dev. 16:693-706(2002)

PubMed=17420292; DOI=10.1083/jcb.200611114; PMCID=PMC2064114
Rene Villadsen, Agla Jael Rubner Fridriksdottir, Lone Ronnov-Jessen, Thorarinn Gudjonsson, Fritz Rank, Mark Alan LaBarge, Mina J. Bissell, Ole William Petersen;
Evidence for a stem cell hierarchy in the adult human breast.
J. Cell Biol. 177:87-101(2007)

PubMed=21915264; DOI=10.1371/journal.pone.0023833; PMCID=PMC3167828
Valgardur Sigurdsson, Bylgja Hilmarsdottir, Hekla Sigmundsdottir, Agla Jael Rubner Fridriksdottir, Markus Ringner, Rene Villadsen, Ake Borg, Bjarni Agnar Agnarsson, Ole William Petersen, Magnus Karl Magnusson, Thorarinn Gudjonsson;
Endothelial induced EMT in breast epithelial cells with stem cell properties.
PLoS ONE 6:e23833.1-e23833.11(2011)

PubMed=30684066; DOI=10.1007/s10911-018-09424-w
Eirikur Briem, Saevar Ingthorsson, Gunnhildur Asta Traustadottir, Bylgja Hilmarsdottir, Thorarinn Gudjonsson;
Application of the D492 cell lines to explore breast morphogenesis, EMT and cancer progression in 3D culture.
J. Mammary Gland Biol. Neoplasia 24:139-147(2019)

Cross-references
Encyclopedic resources Wikidata; Q127380738
Entry history
Entry creation30-Jan-2024
Last entry update14-Aug-2025
Version number3