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Cellosaurus MKL-2 (CVCL_D027)

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Cell line name MKL-2
Synonyms Mkl-2; MKL2
Accession CVCL_D027
Resource Identification Initiative To cite this cell line use: MKL-2 (RRID:CVCL_D027)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Virology: Contains 1.7 copies of the genome of MCPyV per haploid cell (PubMed=23085629).
Doubling time: 5 days (PubMed=20444890); 3 days (PubMed=30873613).
Transformant: NCBI_TaxID; 493803; Merkel cell polyomavirus (MCPyV).
Omics: Array-based CGH.
Omics: Deep quantitative proteome analysis.
Disease Merkel cell carcinoma (NCIt: C9231)
Cutaneous neuroendocrine carcinoma (ORDO: Orphanet_79140)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 72Y
Category Cancer cell line
STR profile Source(s): PubMed=30873613

Penta D10,13
Penta E11,13

Run an STR similarity search on this cell line

PubMed=1717086; DOI=10.1016/0169-6009(91)90088-H
Martin E.M.E., Gould V.E., Hoog A., Rosen S.T., Radosevich J.A., Deftos L.J.
Parathyroid hormone-related protein, chromogranin A, and calcitonin gene products in the neuroendocrine skin carcinoma cell lines MKL1 and MKL2.
Bone Miner. 14:113-120(1991)

PubMed=12209990; DOI=10.1002/ijc.10591
Van Gele M., Leonard J.H., Van Roy N., Van Limbergen H., Van Belle S., Cocquyt V., Salwen H.R., De Paepe A., Speleman F.
Combined karyotyping, CGH and M-FISH analysis allows detailed characterization of unidentified chromosomal rearrangements in Merkel cell carcinoma.
Int. J. Cancer 101:137-145(2002)

PubMed=20444890; DOI=10.1128/JVI.02400-09
Houben R., Shuda M., Weinkam R., Schrama D., Feng H.-C., Chang Y., Moore P.S., Becker J.C.
Merkel cell polyomavirus-infected Merkel cell carcinoma cells require expression of viral T antigens.
J. Virol. 84:7064-7072(2010)

PubMed=23085629; DOI=10.1016/j.jviromet.2012.10.001
Guastafierro A., Feng H., Thant M., Kirkwood J.M., Chang Y., Moore P.S., Shuda M.
Characterization of an early passage Merkel cell polyomavirus-positive Merkel cell carcinoma cell line, MS-1, and its growth in NOD scid gamma mice.
J. Virol. Methods 187:6-14(2013)

PubMed=23563200; DOI=10.1038/jid.2013.169
Houben R., Dreher C., Angermeyer S., Borst A., Utikal J.S., Haferkamp S., Peitsch W.K., Schrama D., Hesbacher S.
Mechanisms of p53 restriction in Merkel cell carcinoma cells are independent of the Merkel cell polyoma virus T antigens.
J. Invest. Dermatol. 133:2453-2460(2013)

PubMed=27121059; DOI=10.18632/oncotarget.8793
Hesbacher S., Pfitzer L., Wiedorfer K., Angermeyer S., Borst A., Haferkamp S., Scholz C.-J., Wobser M., Schrama D., Houben R.
RB1 is the crucial target of the Merkel cell polyomavirus Large T antigen in Merkel cell carcinoma cells.
Oncotarget 7:32956-32968(2016)

PubMed=29696010; DOI=10.3389/fmicb.2018.00713
Velasquez C., Amako Y., Harold A., Toptan T., Chang Y., Shuda M.
Characterization of a Merkel cell polyomavirus-positive Merkel cell carcinoma cell line CVG-1.
Front. Microbiol. 9:713.1-713.10(2018)

PubMed=30873613; DOI=10.1002/ijc.32280
Schrama D., Sarosi E.-M., Adam C., Ritter C., Kaemmerer U., Klopocki E., Konig E.-M., Utikal J.S., Becker J.C., Houben R.
Characterization of six Merkel cell polyomavirus-positive Merkel cell carcinoma cell lines: integration pattern suggest that large T antigen truncating events occur before or during integration.
Int. J. Cancer 145:1020-1032(2019)

PubMed=31889939; DOI=10.1186/s12014-019-9263-z
Kotowski U., Erovic B.M., Schnoll J., Stanek V., Janik S., Steurer M., Mitulovic G.
Quantitative proteome analysis of Merkel cell carcinoma cell lines using SILAC.
Clin. Proteomics 16:42.1-42.13(2019)

Cell line databases/resources Cell_Model_Passport; SIDM01790
DepMap; ACH-001123
Chemistry resources GDSC; 1333015
PharmacoDB; MKL2_935_2019
Encyclopedic resources Wikidata; Q54905817
Polymorphism and mutation databases Cosmic; 1693073
Cosmic; 2273917
Proteomic databases PRIDE; PXD008181
Entry history
Entry creation22-Oct-2012
Last entry update21-Mar-2023
Version number17