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Cellosaurus (CVCL_C9ES)

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Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: LL-100 blood cancer cell line panel.
Part of: MD Anderson Cell Lines Project.
Population: Japanese.
Doubling time: ~48 hours (DSMZ=ACC-552).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene fusion; HGNC; HGNC:7132; KMT2A + HGNC; HGNC:7134; MLLT1; Name(s)=KMT2A-MLLT1, MLL-MLLT1, MLL-ENL (PubMed=31160637; PubMed=35354797; DSMZ=ACC-552).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (Cosmic-CLP=1330933; DepMap=ACH-001106).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (Cosmic-CLP=1330933; DepMap=ACH-001106).
HLA typing Source: PubMed=26589293
Class I
HLA-AA*33:03,33:03
HLA-BB*44:03,44:03
HLA-CC*14:03,14:03

Source: DSMZCellDive=ACC-552
Class I
HLA-AA*33:03:01,33:03:01
HLA-BB*44:03:01,44:03:01
HLA-CC*14:03,14:03
Class II
HLA-DPDPA1*01:03:01,02:02:02
DPB1*04:01:01,02:01:02
HLA-DQDQA1*01:02:01,01:02:01
DQB1*06:09:01,06:09:01
HLA-DRDRA*01:02:02,01:02:02
DRB1*13:02:01,13:02:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African3.7
Native American0
East Asian, North80.77
East Asian, South13.03
South Asian0
European, North0
European, South2.49
Disease Childhood B acute lymphoblastic leukemia (NCIt: C9140)
B acute lymphoblastic leukemia with t(v;11q23.3) MLL rearranged (NCIt: C80342)
B-lymphoblastic leukemia/lymphoma with t(v;11q23.3) (ORDO: Orphanet_585918)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 3M
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=1330933; DSMZ=ACC-552

Markers:
AmelogeninX
CSF1PO10,12
D2S133820,23
D3S135815,16
D5S8189,11
D7S8208,10
D8S117913,16
D13S3178,11
D16S5399,11
D18S5114,22
D19S43313,14
D21S1129
FGA18,21
Penta D12,13
Penta E12,20
TH016,10
TPOX8,11
vWA16,18

Run an STR similarity search on this cell line
Web pages Info; MCLP; -; https://tcpaportal.org/mclp/
Publications


Pierluigi Strippoli, Fabio Tumietto, Roberto Tonelli, Alessandro Maria Vannucchi, Antonella Ronchi, Sergio Ottolenghi, Giovannella Visconti, Gian Carlo Avanzi, Luigi Pegoraro, Gian Paolo Bagnara;
An erythroid and megakaryocytic common precursor cell line (B1647) expressing both c-mpl and erythropoietin receptor (Epo-R) proliferates and modifies globin chain synthesis in response to megakaryocyte growth and development factor (MGDF) but not to erythropoietin (Epo).
Br. J. Haematol. 98:549-559(1997)


Nicholas Constantin Popescu;
Novel genomic imbalances and chromosome translocations involving c-myc gene in Burkitt's lymphoma.
Leukemia 15:1582-1588(2001)



switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K.
Cancer Cell 18:683-695(2010)


Julie Adam, Ann Hedley, Gabriela Kalna, Ian Philip Mark Tomlinson, Patrick John Pollard, David George Watson, Ralph J. DeBerardinis, Tomer Shlomi, Eytan Ruppin, Eyal Gottlieb;
Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase.
Nature 477:225-228(2011)


Hangnoh Lee, Charles Joel McManus, Dong-Yeon Cho, Matthew Eaton, Fioranna Renda, Maria Patrizia Somma, Lucy Cherbas, Gemma May, Sara Powell, Da-Yu Zhang, Li-Jun Zhan ...Show all 20 authors... , Alissa Resch, Justen Andrews, Susan E. Celniker, Peter Cherbas, Teresa Maria Przytycka, Maurizio Gatti, Brian Oliver, Brenton R. Graveley, David M. MacAlpine; Show fewer authors
DNA copy number evolution in Drosophila cell lines.
Genome Biol. 15:R70.1-R70.20(2014)


Yasuhiro Takashima, Ge Guo, Remco Loos, Jennifer Nichols, Gabriella Ficz, Felix Krueger, David Oxley, Fatima Santos, James Clarke, William Mansfield, Wolf Reik ...Show all 13 authors... , Paul Bertone, Austin Gerard Smith; Show fewer authors
Resetting transcription factor control circuitry toward ground-state pluripotency in human.
Cell 158:1254-1269(2014)




BMC Cancer 15:240.1-240.16(2015)



literature.
Cancer Res. 77:2784-2788(2017)


Tetsuhiro Kikuchi, Asuka Morizane, Daisuke Doi, Hiroaki Magotani, Hirotaka Onoe, Takuya Hayashi, Hiroshi Mizuma, Sayuki Takara, Ryosuke Takahashi, Haruhisa Inoue, Satoshi Morita ...Show all 16 authors... , Michio Yamamoto, Keisuke Okita, Masato Nakagawa, Malin Parmar, Jun Takahashi; Show fewer authors
Human iPS cell-derived dopaminergic neurons function in a primate Parkinson's disease model.
Nature 548:592-596(2017)


Richard G. Saul, Jan A. Kaczmarczyk, Suzanne D. Borgel, Sergio Y. Alcoser, Melinda G. Hollingshead, Young H. Lee, Donald P. Bottaro, Tara Hiltke, Gordon R. Whiteley, Naoko Takebe, Robert J. Kinders ...Show all 14 authors... , Ralph E. Parchment, Joseph E. Tomaszewski, James H. Doroshow; Show fewer authors
Novel antibody reagents for characterization of drug- and tumor microenvironment-induced changes in epithelial-mesenchymal transition and cancer stem cells.
PLoS ONE 13:e0199361.1-e0199361.24(2018)




Cancer Cell 33:386-400.e5(2018)


Elisabeth Kremmer, Thomas Zobel, Jochen Dobner, Nicole Bleffert, Sandra Hoffmann, Dieter Willbold;
The highly GABARAP specific rat monoclonal antibody 8H5 visualizes GABARAP in immunofluorescence imaging at endogenous levels.
Sci. Rep. 9:526.1-526.11(2019)




Nat. Commun. 11:74.1-74.16(2020)

Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number39