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Cellosaurus HepG2-NTCP1 HBV (CVCL_C9BA)

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Cell line name HepG2-NTCP1 HBV
Synonyms HepG2-HBV
Accession CVCL_C9BA
Resource Identification Initiative To cite this cell line use: HepG2-NTCP1 HBV (RRID:CVCL_C9BA)
Comments Population: Caucasian.
Virology: Contains a stably integrated 1.3 mer copy of the Hepatitis B virus (HBV) subtype AYW genome (PubMed=26438841).
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:10905; SLC10A1.
Genetic integration: Method=Transduction; Gene=UniProtKB; P33967; Bacillus cereus Bsr.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Hepatoblastoma (NCIt: C3728)
Hepatoblastoma (ORDO: Orphanet_449)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_C9B9 (HepG2-NTCP1)
Children:
CVCL_C9BB (HepG2-NTCP1 HBV Cas9)
Sex of cell Male
Age at sampling 15Y
Category Cancer cell line
Publications

PubMed=26438841; DOI=10.1073/pnas.1518090112; PMCID=PMC4620859
Philipp Tropberger, Alexandre Mercier, Margaret Robinson, Wei-Dong Zhong, Donald Emil Ganem, Meghan Holdorf;
Mapping of histone modifications in episomal HBV cccDNA uncovers an unusual chromatin organization amenable to epigenetic manipulation.
Proc. Natl. Acad. Sci. U.S.A. 112:E5715-E5724(2015)

PubMed=31801065; DOI=10.1016/j.celrep.2019.10.113
Anastasia Hyrina, Christopher Jones, Darlene Chen, Scott Clarkson, Nadire Cochran, Paul Feucht, Gregory Hoffman, Alicia Lindeman, Carsten Russ, Frederic Sigoillot, Tiffany Tsang ...Show all 15 authors... , Kyoko Uehara, Li-Li Xie, Donald Emil Ganem, Meghan Holdorf; Show fewer authors
A genome-wide CRISPR screen identifies ZCCHC14 as a host factor required for hepatitis B surface antigen production.
Cell Rep. 29:2970-2978.e6(2019)

Cross-references
Encyclopedic resources Wikidata; Q123031639
Entry history
Entry creation05-Oct-2023
Last entry update14-Aug-2025
Version number5