Cellosaurus cell line RC2 102 37 Cr-1 (CVCL

Cellosaurus RC2 102 37 Cr-1 (CVCL_C935)

Cross-references
Cell line name	RC2 102 37 Cr-1
Synonyms	102 37Cr-1; RC2 102; PiZZ102
Accession	CVCL_C935
Resource Identification Initiative	To cite this cell line use: RC2 102 37 Cr-1 (RRID:CVCL_C935)
Comments	From: Center for Regenerative Medicine; Boston; USA. Population: Caucasian. Derived from site: In situ; Skin, dermis; UBERON=UBERON_0002067. Cell type: Fibroblast of skin; CL=CL_0002620.
Sequence variations	Mutation; HGNC; HGNC:8941; SERPINA1; Simple; p.Glu366Lys (c.1096G>A); ClinVar=VCV000017967; Zygosity=Homozygous; Note=Z allele (PubMed=20715179; PubMed=32619491).
Disease	Alpha-1 antitrypsin deficiency (NCIt: C84397) Alpha-1 antitrypsin deficiency (ORDO: Orphanet_60)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual	CVCL_C936 ! RC2 102 37 Cr-3
Sex of cell	Female
Age at sampling	51Y
Category	Induced pluripotent stem cell
Web pages	Provider; CReM; 525; https://stemcellbank.bu.edu/Catalog/Item/Details/525
Publications	PubMed=20715179; DOI=10.1002/stem.495; PMCID=PMC3422663 Aba Somers, Jyh-Chang Jean, Cesar A. Sommer, Amel Omari, Christopher C. Ford, Jason A. Mills, Lei Ying, Andreia Gianotti-Sommer, Jenny M. Jean, Brenden W. Smith, Robert Lafyatis ...Show all 18 authors... , Marie-France Demierre, Daniel J. Weiss, Deborah L. French, Paul Gadue, George J. Murphy, Gustavo Mostoslavsky, Darrell N. Kotton; Show fewer authors Generation of transgene-free lung disease-specific human induced pluripotent stem cells using a single excisable lentiviral stem cell cassette. Stem Cells 28:1728-1740(2010) PubMed=32619491; DOI=10.1016/j.stemcr.2020.06.006; PMCID=PMC7363960 Joseph E. Kaserman, Killian Hurley, Mark Dodge, Carlos Villacorta-Martin, Marall Vedaie, Jyh-Chang Jean, Derek C. Liberti, Marianne F. James, Michelle I. Higgins, Nora J. Lee, George Richard Washko ...Show all 15 authors... , Raul San Jose Estepar, Jeffrey Teckman, Darrell N. Kotton, Andrew A. Wilson; Show fewer authors A highly phenotyped open access repository of alpha-1 antitrypsin deficiency pluripotent stem cells. Stem Cell Reports 15:242-255(2020)
Encyclopedic resources	Wikidata; Q54949422
Entry history
Entry creation	22-Oct-2012
Last entry update	10-Apr-2025
Version number	19