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Cellosaurus TC-797 (CVCL_C8YZ)

[Text version]
Cell line name TC-797
Synonyms TC797; NMC 797; NMC797; 797
Accession CVCL_C8YZ
Resource Identification Initiative To cite this cell line use: TC-797 (RRID:CVCL_C8YZ)
Comments Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; RNAseq.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
Disease NUT carcinoma (NCIt: C45716)
NUT midline carcinoma (ORDO: Orphanet_443167)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 15Y
Category Cancer cell line
Publications

PubMed=12796605; DOI=10.1097/01.COC.0000020960.98562.84
Jeffrey A. Toretsky, James Jenson, Chen-Chih Sun, Allen E. Eskenazi, Andrew Campbell, Stephen P. Hunger, Aimee Caires, Christopher Frantz, John Laurance Hill, Judith Stamberg;
Translocation (11;15;19): a highly specific chromosome rearrangement associated with poorly differentiated thymic carcinoma in young patients.
Am. J. Clin. Oncol. 26:300-306(2003)

PubMed=17934517; DOI=10.1038/sj.onc.1210852
Christopher Alexander French, Cherie L. Ramirez, Julia Kolmakova, Tyler T. Hickman, Michael J. Cameron, M.E. Thyne, Jeffery L. Kutok, Jeffrey A. Toretsky, A.K. Tadavarthy, Ursula R. Kees, Jonathan A. Fletcher, Jon Christopher Aster;
BRD-NUT oncoproteins: a family of closely related nuclear proteins that block epithelial differentiation and maintain the growth of carcinoma cells.
Oncogene 27:2237-2242(2008)

PubMed=20871596; DOI=10.1038/nature09504; PMCID=PMC3010259
Panagis Filippakopoulos, Jun Qi, Sarah Picaud, Yao Shen, William B. Smith, Oleg Fedorov, Elizabeth M. Morse, Tracey Keates, Tyler T. Hickman, Ildiko Felletar, Martin Philpott ...Show all 25 authors... , Shonagh Munro, Michael R. McKeown, Yu-Chuan Wang, Amanda L. Christie, Nathan H. West, Michael J. Cameron, Brian E. Schwartz, Tom D. Heightman, Nicholas Barrie La Thangue, Christopher Alexander French, Olaf Wiest, Andrew Li-Jen Kung, Stefan Knapp, James E. Bradner; Show fewer authors
Selective inhibition of BET bromodomains.
Nature 468:1067-1073(2010)

PubMed=21447744; DOI=10.1158/0008-5472.CAN-10-3513; PMCID=PMC3070805
Brian E. Schwartz, Matthias D. Hofer, Madeleine E. Lemieux, Daniel Evan Bauer, Michael J. Cameron, Nathan H. West, Elin S. Agoston, Nicolas Reynoird, Saadi Khochbin, Tan A. Ince, Amanda L. Christie ...Show all 19 authors... , Katherine A. Janeway, Sara Oakes Vargas, Antonio Rafael Perez-Atayde, Jon Christopher Aster, Stephen Earl Sallan, Andrew L. Kung, James E. Bradner, Christopher Alexander French; Show fewer authors
Differentiation of NUT midline carcinoma by epigenomic reprogramming.
Cancer Res. 71:2686-2696(2011)

PubMed=29348827; DOI=10.18632/oncotarget.22862; PMCID=PMC5762512
Anja Stirnweiss, Joyce Oommen, Rishi S. Kotecha, Ursula R. Kees, Alex H. Beesley;
Molecular-genetic profiling and high-throughput in vitro drug screening in NUT midline carcinoma-an aggressive and fatal disease.
Oncotarget 8:112313-112329(2017)

PubMed=30135075; DOI=10.1101/gad.315648.118; PMCID=PMC6120715
Sida Liao, Ophelia Maertens, Karen Marie Cichowski, Stephen Joseph Elledge;
Genetic modifiers of the BRD4-NUT dependency of NUT midline carcinoma uncovers a synergism between BETis and CDK4/6is.
Genes Dev. 32:1188-1200(2018)

Cross-references
Encyclopedic resources Wikidata; Q123033608
Entry history
Entry creation05-Oct-2023
Last entry update10-Apr-2025
Version number4