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Cellosaurus SKOV3 (R) (CVCL_C8XP)

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Cell line name SKOV3 (R)
Accession CVCL_C8XP
Resource Identification Initiative To cite this cell line use: SKOV3 (R) (RRID:CVCL_C8XP)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_45863; Paclitaxel (Taxol).
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; HGNC:583; APC; Simple; p.Thr1556Leufs*9 (c.4666delA); ClinVar=VCV000156477; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg505Leu (c.1514G>T); ClinVar=VCV000376424; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ser90Profs*33 (c.267delC); ClinVar=VCV000156515; Zygosity=Homozygous (from parent cell line).
Disease Ovarian serous cystadenocarcinoma (NCIt: C7978)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0532 (SK-OV-3)
Sex of cell Female
Age at sampling 64Y
Category Cancer cell line
Publications

PubMed=33519462; DOI=10.3389/fphar.2020.600994; PMCID=PMC7838559
Ya-Qing Zhang, Hong-Yun Gan, Fei Zhao, Xiao-Mei Ma, Xiao-Feng Xie, Rui Huang, Jin Zhao;
CPEB4-promoted paclitaxel resistance in ovarian cancer in vitro relies on translational regulation of CSAG2.
Front. Pharmacol. 11:600994.1-600994.10(2020)

Cross-references
Encyclopedic resources Wikidata; Q123033517
Entry history
Entry creation05-Oct-2023
Last entry update19-Dec-2024
Version number3