| Cell line name |
CUTO-9 |
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| Synonyms |
CUTO9; Colorado University Thoracic Oncology 9 |
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| Accession |
CVCL_C8TB |
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| Resource Identification Initiative |
To cite this cell line use: CUTO-9 (RRID:CVCL_C8TB) |
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| Comments |
Doubling time: 26 +- 0.6 hours (PubMed=35933914).
Omics: Genomics; Whole genome sequencing.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795. |
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| Sequence variations |
- Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Heterozygous (PubMed=35933914).
- Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Heterozygous (PubMed=35933914).
- Gene fusion; HGNC; HGNC:427; ALK + HGNC; HGNC:1316; EML4; Name(s)=EML4-ALK; Note=E13A20 v1 fusion (PubMed=35933914).
- Mutation; HGNC; HGNC:18040; ARID1B; Simple; p.Pro1838fs*22 (c.5513delC) (p.Pro1851fs*22, c.5552delC); Zygosity=Heterozygous (PubMed=35933914).
- Mutation; HGNC; HGNC:7765; NF1; Simple; p.Gln642Ter (c.1924C>T); ClinVar=VCV000952282; Zygosity=Heterozygous (PubMed=35933914).
|
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| Disease |
Lung adenocarcinoma (NCIt: C3512) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Sex of cell |
Male |
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| Age at sampling |
41Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=35933914; DOI=10.1016/j.lungcan.2022.07.010
Abdulmalik Asaadallah A. Bokhari, Wei-Yun Lai, Anh T. Le, Jonatan L. Gabre, Tzu-Po Chuang, Susanne Fransson, Bengt Bergman, Anna Djos, N. Chen, Tommy Martinsson, Jimmy Van den Eynden ...Show all 15 authors... , Robert C. Doebele, Ruth H. Palmer, Bengt Hallberg, Ganesh Umapathy; Show fewer authors
Novel human-derived EML4-ALK fusion cell lines identify ribonucleotide reductase RRM2 as a target of activated ALK in NSCLC.
Lung Cancer 171:103-114(2022) |
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| Cross-references |
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| Encyclopedic resources |
Wikidata; Q123031003
|
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| Gene expression databases |
ArrayExpress; E-MTAB-11342
|
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| Entry history |
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| Entry creation | 05-Oct-2023 |
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| Last entry update | 10-Apr-2025 |
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| Version number | 4 |
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