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Cellosaurus CUTO-8 (CVCL_C8T9)

[Text version]
Cell line name CUTO-8
Synonyms CUTO8; Colorado University Thoracic Oncology 8
Accession CVCL_C8T9
Resource Identification Initiative To cite this cell line use: CUTO-8 (RRID:CVCL_C8T9)
Comments Doubling time: 28 +- 3.1 hours (PubMed=35933914).
Omics: Genomics; Whole genome sequencing.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=35933914).
  • Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (PubMed=35933914).
  • Gene fusion; HGNC; HGNC:427; ALK + HGNC; HGNC:1316; EML4; Name(s)=EML4-ALK; Note=E13A20 v1 fusion (DOI=10.1101/2022.06.08.495301; PubMed=35933914).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gly293fs*13 (c.876dupA); Zygosity=Homozygous (PubMed=35933914).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 66Y
Category Cancer cell line
Publications

DOI=10.1101/2022.06.08.495301
Licciardello M.P., Zhang C., Le A.T., Doebele R.C., Clarke P.A., Workman P.
Loss of spindly sensitizes EML4-ALK v3 lung cancer cells to HSP90 inhibitors.
bioRxiv 2022:06.08.495301-06.08.495301(2022)

PubMed=35933914; DOI=10.1016/j.lungcan.2022.07.010
Bokhari A.A.A., Lai W.-Y., Le A.T., Gabre J.L., Chuang T.-P., Fransson S., Bergman B., Djos A., Chen N., Martinsson T., Van den Eynden J., Doebele R.C., Palmer R.H., Hallberg B., Umapathy G.
Novel human-derived EML4-ALK fusion cell lines identify ribonucleotide reductase RRM2 as a target of activated ALK in NSCLC.
Lung Cancer 171:103-114(2022)

Cross-references
Encyclopedic resources Wikidata; Q123031002
Gene expression databases ArrayExpress; E-MTAB-11342
Entry history
Entry creation05-Oct-2023
Last entry update10-Apr-2025
Version number4