| Cell line name |
CUTO-8 |
|---|
| Synonyms |
CUTO8; Colorado University Thoracic Oncology 8 |
|---|
| Accession |
CVCL_C8T9 |
|---|
| Resource Identification Initiative |
To cite this cell line use: CUTO-8 (RRID:CVCL_C8T9) |
|---|
| Comments |
Doubling time: 28 +- 3.1 hours (PubMed=35933914).
Omics: Genomics; Whole genome sequencing.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175. |
|---|
| Sequence variations |
- Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=35933914).
- Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (PubMed=35933914).
- Gene fusion; HGNC; HGNC:427; ALK + HGNC; HGNC:1316; EML4; Name(s)=EML4-ALK; Note=E13A20 v1 fusion (DOI=10.1101/2022.06.08.495301; PubMed=35933914).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gly293fs*13 (c.876dupA); Zygosity=Homozygous (PubMed=35933914).
|
|---|
| Disease |
Lung adenocarcinoma (NCIt: C3512) |
|---|
| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
|---|
| Sex of cell |
Female |
|---|
| Age at sampling |
66Y |
|---|
| Category |
Cancer cell line |
|---|
| Publications | DOI=10.1101/2022.06.08.495301
Marco P. Licciardello, Chi Zhang, Anh T. Le, Robert C. Doebele, Paul A. Clarke, Paul Workman;
Loss of spindly sensitizes EML4-ALK v3 lung cancer cells to HSP90 inhibitors.
bioRxiv 2022:06.08.495301-06.08.495301(2022) PubMed=35933914; DOI=10.1016/j.lungcan.2022.07.010
Abdulmalik Asaadallah A. Bokhari, Wei-Yun Lai, Anh T. Le, Jonatan L. Gabre, Tzu-Po Chuang, Susanne Fransson, Bengt Bergman, Anna Djos, N. Chen, Tommy Martinsson, Jimmy Van den Eynden ...Show all 15 authors... , Robert C. Doebele, Ruth H. Palmer, Bengt Hallberg, Ganesh Umapathy; Show fewer authors
Novel human-derived EML4-ALK fusion cell lines identify ribonucleotide reductase RRM2 as a target of activated ALK in NSCLC.
Lung Cancer 171:103-114(2022) |
|---|
| Cross-references |
|---|
| Encyclopedic resources |
Wikidata; Q123031002
|
|---|
| Gene expression databases |
ArrayExpress; E-MTAB-11342
|
|---|
| Entry history |
|---|
| Entry creation | 05-Oct-2023 |
|---|
| Last entry update | 10-Apr-2025 |
|---|
| Version number | 4 |
|---|
