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Cellosaurus MCF-7 AC1-ExR (CVCL_C8NC)

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Cell line name MCF-7 AC1-ExR
Synonyms AC1-ExR
Accession CVCL_C8NC
Resource Identification Initiative To cite this cell line use: MCF-7 AC1-ExR (RRID:CVCL_C8NC)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_4953; Exemestane (Aromasin).
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:2594; CYP19A1.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_C8MT (MCF-7 AC1)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

DOI=10.1158/1538-7445.AM2013-520
Joyce C. Ohiri, Armina A. Kazi, Amanda J. Schech, Angela Mary Hartley Brodie;
Characterizing the AC1-exemestane resistant cell line to reveal the underlying mechanism of resistance to aromatase inhibitors in estrogen-dependent breast cancer.
Cancer Res. 73 Suppl. 8:520-520(2013)

PubMed=24472707; DOI=10.1186/bcr3609; PMCID=PMC3978891
Armina A. Kazi, Rabia A. Gilani, Amanda J. Schech, Saranya Chumsri, Gauri J. Sabnis, Preeti Shah, Olga Goloubeva, Shari S. Kronsberg, Angela Mary Hartley Brodie;
Nonhypoxic regulation and role of hypoxia-inducible factor 1 in aromatase inhibitor resistant breast cancer.
Breast Cancer Res. 16:R15.1-R15.18(2014)

Cross-references
Encyclopedic resources Wikidata; Q123033006
Entry history
Entry creation05-Oct-2023
Last entry update14-Aug-2025
Version number5