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Cellosaurus K562/fes clone WS-6 (CVCL_C8IQ)

[Text version]
Cell line name K562/fes clone WS-6
Synonyms K562/WS-6; WS-6
Accession CVCL_C8IQ
Resource Identification Initiative To cite this cell line use: K562/fes clone WS-6 (RRID:CVCL_C8IQ)
Comments Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:12841; YES1.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln136fs*13 (c.406_407insC); Zygosity=Homozygous (from parent cell line).
Disease Blast phase chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C9110)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0004 (K-562)
Sex of cell Female
Age at sampling 53Y
Category Cancer cell line
Publications

PubMed=2656706; DOI=10.1016/S0021-9258(18)81796-3
Gang Yu, Thomas E. Smithgall, Robert I. Glazer;
K562 leukemia cells transfected with the human c-fes gene acquire the ability to undergo myeloid differentiation.
J. Biol. Chem. 264:10276-10281(1989)

Cross-references
Encyclopedic resources Wikidata; Q123032789
Entry history
Entry creation05-Oct-2023
Last entry update14-Aug-2025
Version number6