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Cellosaurus OS457 (CVCL_C8FV)

[Text version]
Cell line name OS457
Accession CVCL_C8FV
Resource Identification Initiative To cite this cell line use: OS457 (RRID:CVCL_C8FV)
Comments Characteristics: Established from a patient-derived xenograft established by implantation of the original tumor under the renal capsule of NSG mice (PubMed=37703185).
Characteristics: Not metastatic (PubMed=37703185).
Omics: Genomics; Whole genome sequencing.
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Bone, humerus; UBERON=UBERON_0000976.
Disease Osteosarcoma (NCIt: C9145)
Osteosarcoma (ORDO: Orphanet_668)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 17Y
Category Cancer cell line
STR profile Source(s): PubMed=37703185

Markers:
AmelogeninX,Y
CSF1PO10,12
D5S8187,13
D7S8208,14
D13S31710,11
D16S53910
TH016,7
TPOX8,11
vWA16

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Publications

PubMed=37703185; DOI=10.1158/1078-0432.CCR-23-0873; PMCID=PMC10870121
Schott C.R., Koehne A.L., Sayles L.C., Young E.P., Luck C., Yu K., Lee A.G., Breese M.R., Leung S.G., Xu H., Shah A.T., Liu H.-Y., Spillinger A., Behroozfard I.H., Marini K.D., Dinh P.T., Pons-Ventura M.V., Vanderboon E.N., Hazard F.K., Cho S.-J., Avedian R.S., Mohler D.G., Zimel M., Wustrack R., Curtis C., Sirota M., Sweet-Cordero E.A.
Osteosarcoma PDX-derived cell line models for preclinical drug evaluation demonstrate metastasis inhibition by dinaciclib through a genome-targeted approach.
Clin. Cancer Res. 30:849-864(2024)

Cross-references
Encyclopedic resources Wikidata; Q123033225
Entry history
Entry creation29-Jun-2023
Last entry update10-Apr-2025
Version number3