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Cellosaurus OS384 (CVCL_C8FU)

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Cell line name OS384
Synonyms PSS131R
Accession CVCL_C8FU
Resource Identification Initiative To cite this cell line use: OS384 (RRID:CVCL_C8FU)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Characteristics: Established from a patient-derived xenograft established by implantation of the original tumor under the renal capsule of NSG mice (PubMed=37703185).
Characteristics: Metastatic (PubMed=37703185).
Omics: Genomics; Whole genome sequencing.
Omics: Transcriptomics; RNAseq.
Miscellaneous: Equivalence of OS384 with PSS131R from personal communication of Sayles, Leanne C.
Derived from site: In situ; Bone, tibia; UBERON=UBERON_0000979.
Disease Osteosarcoma (NCIt: C9145)
Osteosarcoma (ORDO: Orphanet_668)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 12Y
Category Cancer cell line
STR profile Source(s): PubMed=37703185

Markers:
AmelogeninX
CSF1PO11,12
D5S81811,12
D7S82011,12
D13S3179
D16S53912,13
TH017
TPOX8,11
vWA16,18

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Publications

PubMed=37703185; DOI=10.1158/1078-0432.CCR-23-0873; PMCID=PMC10870121
Courtney R. Schott, Amanda Lynn Koehne, Leanne C. Sayles, Elizabeth P. Young, Cuyler Luck, Katharine Yu, Alex G. Lee, Marcus R. Breese, Stanley G. Leung, Hang Xu, Avanthi Tayi Shah ...Show all 27 authors... , Heng-Yi Liu, Aviv Spillinger, Inge H. Behroozfard, Kieren D. Marini, Phuong T. Dinh, Maria Victoria Pons-Ventura, Emma N. Vanderboon, Florette K. Hazard, Soo-Jin Cho, Raffi S. Avedian, David G. Mohler, Melissa Zimel, Rosanna Wustrack, Christina Curtis, Marina Sirota, Eric Alejandro Sweet-Cordero; Show fewer authors
Osteosarcoma PDX-derived cell line models for preclinical drug evaluation demonstrate metastasis inhibition by dinaciclib through a genome-targeted approach.
Clin. Cancer Res. 30:849-864(2024)

Cross-references
Cell line databases/resources DepMap; ACH-002834
Encyclopedic resources Wikidata; Q123033223
Entry history
Entry creation29-Jun-2023
Last entry update10-Apr-2025
Version number5