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Cellosaurus OS186 (CVCL_C8FT)

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Cell line name OS186
Accession CVCL_C8FT
Resource Identification Initiative To cite this cell line use: OS186 (RRID:CVCL_C8FT)
Comments Characteristics: Established from a patient-derived xenograft established by implantation of the original tumor under the renal capsule of NSG mice (PubMed=37703185).
Characteristics: Not metastatic (PubMed=37703185).
Omics: Genomics; Whole genome sequencing.
Omics: Transcriptomics; RNAseq.
Derived from site: Metastatic; Bone, jaw, mandible; UBERON=UBERON_0001684.
Disease Osteosarcoma (NCIt: C9145)
Osteosarcoma (ORDO: Orphanet_668)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 13Y
Category Cancer cell line
STR profile Source(s): PubMed=37703185

Markers:
AmelogeninX,Y
CSF1PO11,12
D5S81810,12
D7S82010,11
D13S3178
D16S53910,13
TH017
TPOX8,11
vWA16,18,19

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Publications

PubMed=37703185; DOI=10.1158/1078-0432.CCR-23-0873; PMCID=PMC10870121
Courtney R. Schott, Amanda Lynn Koehne, Leanne C. Sayles, Elizabeth P. Young, Cuyler Luck, Katharine Yu, Alex G. Lee, Marcus R. Breese, Stanley G. Leung, Hang Xu, Avanthi Tayi Shah ...Show all 27 authors... , Heng-Yi Liu, Aviv Spillinger, Inge H. Behroozfard, Kieren D. Marini, Phuong T. Dinh, Maria Victoria Pons-Ventura, Emma N. Vanderboon, Florette K. Hazard, Soo-Jin Cho, Raffi S. Avedian, David G. Mohler, Melissa Zimel, Rosanna Wustrack, Christina Curtis, Marina Sirota, Eric Alejandro Sweet-Cordero; Show fewer authors
Osteosarcoma PDX-derived cell line models for preclinical drug evaluation demonstrate metastasis inhibition by dinaciclib through a genome-targeted approach.
Clin. Cancer Res. 30:849-864(2024)

Cross-references
Encyclopedic resources Wikidata; Q123033222
Entry history
Entry creation29-Jun-2023
Last entry update10-Apr-2025
Version number3