Cellosaurus logo
expasy logo

Cellosaurus OS052 (CVCL_C8FR)

[Text version]
Cell line name OS052
Synonyms PSS008
Accession CVCL_C8FR
Resource Identification Initiative To cite this cell line use: OS052 (RRID:CVCL_C8FR)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Characteristics: Established from a patient-derived xenograft established by implantation of the original tumor under the renal capsule of NSG mice (PubMed=37703185).
Characteristics: Metastatic (PubMed=37703185).
Omics: Genomics; Whole genome sequencing.
Omics: Transcriptomics; RNAseq.
Miscellaneous: Equivalence of OS052 with PSS008 from personal communication of Sayles, Leanne C.
Derived from site: In situ; Bone, fibula; UBERON=UBERON_0001446.
Sequence variations
  • Mutation; HGNC; HGNC:9884; RB1; Simple; p.Glu465Lysfs*13 (c.1392delA) (c.1391delA); ClinVar=VCV000954138; Zygosity=Homozygous (DepMap=ACH-002471).
Disease Osteosarcoma (NCIt: C9145)
Osteosarcoma (ORDO: Orphanet_668)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 17Y
Category Cancer cell line
STR profile Source(s): PubMed=37703185

Markers:
AmelogeninX
CSF1PO11,12
D5S81811
D7S8209,11
D13S31713
D16S53911
TH019.3
TPOX8
vWA17,18

Run an STR similarity search on this cell line
Publications

PubMed=37703185; DOI=10.1158/1078-0432.CCR-23-0873; PMCID=PMC10870121
Courtney R. Schott, Amanda Lynn Koehne, Leanne C. Sayles, Elizabeth P. Young, Cuyler Luck, Katharine Yu, Alex G. Lee, Marcus R. Breese, Stanley G. Leung, Hang Xu, Avanthi Tayi Shah ...Show all 27 authors... , Heng-Yi Liu, Aviv Spillinger, Inge H. Behroozfard, Kieren D. Marini, Phuong T. Dinh, Maria Victoria Pons-Ventura, Emma N. Vanderboon, Florette K. Hazard, Soo-Jin Cho, Raffi S. Avedian, David G. Mohler, Melissa Zimel, Rosanna Wustrack, Christina Curtis, Marina Sirota, Eric Alejandro Sweet-Cordero; Show fewer authors
Osteosarcoma PDX-derived cell line models for preclinical drug evaluation demonstrate metastasis inhibition by dinaciclib through a genome-targeted approach.
Clin. Cancer Res. 30:849-864(2024)

Cross-references
Cell line databases/resources DepMap; ACH-002471
Encyclopedic resources Wikidata; Q123033220
Entry history
Entry creation29-Jun-2023
Last entry update10-Apr-2025
Version number7