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Cellosaurus J82/MMC (CVCL_C8D4)

[Text version]
Cell line name J82/MMC
Accession CVCL_C8D4
Resource Identification Initiative To cite this cell line use: J82/MMC (RRID:CVCL_C8D4)
Comments Population: Caucasian; Swedish.
Selected for resistance to: ChEBI; CHEBI:27504; Mitomycin C (MMC; MitC).
Derived from site: In situ; Urinary bladder; UBERON=UBERON_0001255.
Sequence variations
  • Mutation; HGNC; 583; APC; Simple; p.Ser770Pro (c.2308T>C); ClinVar=VCV000140988; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Pro124Leu (c.371C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Asn212fs*1 (c.635_1212del578); Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 9884; RB1; Simple; c.2107-2A>G; ClinVar=VCV000013077; Zygosity=Homozygous; Note=Splice acceptor mutation (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Glu271Lys (c.811G>A); ClinVar=VCV000406566; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Lys320Asn (c.960G>C); Zygosity=Heterozygous (from parent cell line).
Disease Bladder carcinoma (NCIt: C4912)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0359 (J82)
Sex of cell Male
Age at sampling 58Y
Category Cancer cell line
Publications

PubMed=8077054; DOI=10.1002/ijc.2910580512
Xu B.H., Gupta V., Singh S.V.
Characterization of a human bladder cancer cell line selected for resistance to mitomycin C.
Int. J. Cancer 58:686-692(1994)

PubMed=7729958; DOI=10.1002/ijc.2910610326
Singh S.V., Xu B.H., Jani J.P., Emerson E.O., Backes M.G., Rihn C., Scalamogna D., Stemmler N., Specht S., Blanock K., Katoh A., Gupta V.
Mechanism of cross-resistance to cisplatin in a mitomycin C-resistant human bladder cancer cell line.
Int. J. Cancer 61:431-436(1995)

Cross-references
Encyclopedic resources Wikidata; Q123032760
Entry history
Entry creation29-Jun-2023
Last entry update30-Jan-2024
Version number2