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Cellosaurus NZel-1 (CVCL_C8BG)

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Cell line name NZel-1
Accession CVCL_C8BG
Resource Identification Initiative To cite this cell line use: NZel-1 (RRID:CVCL_C8BG)
Comments Characteristics: Defective in alkyldihydroxyacetone phosphate (DHAP) synthase (PubMed=9114014).
Characteristics: Selected using the 9-(1'-pyrene)nonanol/ultraviolet (P9OH/UV) method. P9OH acts as a photosensitizer. Normal cells which can incorporate the fluorescent fatty alcohol into lipids are killed by UV, but mutants who incorporate P9OH poorly are less susceptible to photosensitized killing.
Transformant: ChEBI; CHEBI_23994; Ethyl methanesulfonate (Methylsulfonic acid ethyl ester; MSEE).
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Cell type: Epithelial cell of ovary; CL=CL_2000064.
Species of origin Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (NCBI Taxonomy: 10029)
Hierarchy Parent: CVCL_0214 (CHO-K1)
Sex of cell Female
Age at sampling Adult
Category Transformed cell line
Publications

PubMed=9114014; DOI=10.1073/pnas.94.9.4475; PMCID=PMC20747
Narasimhan Nagan, Amiya K. Hajra, Arun K. Das, Hugo Wolfgang Moser, Ann Boody Moser, Paul Lazarow, P. Edward Purdue, Raphael A. Zoeller;
A fibroblast cell line defective in alkyl-dihydroxyacetone phosphate synthase: a novel defect in plasmalogen biosynthesis.
Proc. Natl. Acad. Sci. U.S.A. 94:4475-4480(1997)

PubMed=9576878; DOI=10.1042/bj3320273; PMCID=PMC1219478
Narasimhan Nagan, Amiya K. Hajra, Leslie K. Larkins, Paul Lazarow, P. Edward Purdue, William B. Rizzo, Raphael A. Zoeller;
Isolation of a Chinese hamster fibroblast variant defective in dihydroxyacetonephosphate acyltransferase activity and plasmalogen biosynthesis: use of a novel two-step selection protocol.
Biochem. J. 332:273-279(1998)

Cross-references
Encyclopedic resources Wikidata; Q123033202
Entry history
Entry creation29-Jun-2023
Last entry update19-Dec-2024
Version number3