• Mutation; HGNC; HGNC:427; ALK; Simple; p.Phe1174Leu (c.3522C>A); ClinVar=VCV000217852; Zygosity=Heterozygous (PubMed=18923523).
  

PubMed=7838528
Ngan Ching Cheng, Nadine Van Roy, Alvin Chan, Mabel Beitsma, Andries Westerveld, Frank Speleman, Rogier Versteeg;
Deletion mapping in neuroblastoma cell lines suggests two distinct tumor suppressor genes in the 1p35-36 region, only one of which is associated with N-myc amplification.
Oncogene 10:291-297(1995)

PubMed=18923523; DOI=10.1038/nature07398
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Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma.
Nature 455:967-970(2008)

PubMed=20655465; DOI=10.1016/j.cell.2010.06.004; PMCID=PMC2913027
Michael Holzel, Si-Dong Huang, Jan Koster, Ingrid Ora, Arjan Lakeman, Huib Nicolaas Caron, Wouter Nijkamp, Jing Xie, Tom Callens, Shahab Asgharzadeh, Robert C. Seeger ...Show all 14 authors... , Ludwine M. Messiaen, Rogier Versteeg, Rene Bernards; Show fewer authors
NF1 is a tumor suppressor in neuroblastoma that determines retinoic acid response and disease outcome.
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PubMed=22213050; DOI=10.1002/ijc.27415; PMCID=PMC3757132
Joanna E. Gawecka, Dirk Geerts, Jan Koster, Maisel J. Caliva, Florian J. Sulzmaier, John Opoku-Ansah, Randal K. Wada, Andre S. Bachmann, Joe W. Ramos;
PEA15 impairs cell migration and correlates with clinical features predicting good prognosis in neuroblastoma.
Int. J. Cancer 131:1556-1568(2012)