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Cellosaurus MM488 (CVCL_C846)

[Text version]
Cell line name MM488
Synonyms MM 488
Accession CVCL_C846
Resource Identification Initiative To cite this cell line use: MM488 (RRID:CVCL_C846)
Comments Omics: CNV analysis.
Omics: SNP array analysis.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (PubMed=17363583).
  • Gene deletion; HGNC; 9588; PTEN; Zygosity=Homozygous (PubMed=17363583).
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (PubMed=17363583).
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=9354451
Castellano M., Pollock P.M., Walters M.K., Sparrow L.E., Down L.M., Gabrielli B.G., Parsons P.G., Hayward N.K.
CDKN2A/p16 is inactivated in most melanoma cell lines.
Cancer Res. 57:4868-4875(1997)

PubMed=10070891; DOI=10.1038/sj.bjc.6690147
Zerp S.F., van Elsas A., Peltenburg L.T.C., Schrier P.I.
p53 mutations in human cutaneous melanoma correlate with sun exposure but are not always involved in melanomagenesis.
Br. J. Cancer 79:921-926(1999)

PubMed=17363583; DOI=10.1158/0008-5472.CAN-06-4152
Stark M.S., Hayward N.K.
Genome-wide loss of heterozygosity and copy number analysis in melanoma using high-density single-nucleotide polymorphism arrays.
Cancer Res. 67:2632-2642(2007)

Cross-references
Cell line databases/resources cancercelllines; CVCL_C846
Encyclopedic resources Wikidata; Q54906151
Gene expression databases GEO; GSM226725
Polymorphism and mutation databases Cosmic; 928701
Progenetix; CVCL_C846
Entry history
Entry creation22-Oct-2012
Last entry update05-Oct-2023
Version number14