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Cellosaurus AF10 [Human myeloma] (CVCL_C833)

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Cell line name AF10 [Human myeloma]
Synonyms AF-10
Accession CVCL_C833
Resource Identification Initiative To cite this cell line use: AF10 [Human myeloma] (RRID:CVCL_C833)
Comments Population: Caucasian.
Characteristics: Produces IgE lambda (from parent cell line).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: Plasma cell; CL=CL_0000786.
Sequence variations
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Lys601Asn (c.1803A>T); ClinVar=VCV000376285; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7329; MSH6; Simple; p.Gly141Asp (c.422G>A); ClinVar=VCV001491786; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ala161Thr (c.481G>A); ClinVar=VCV000161518; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:12033; TRAF3; Simple; p.Lys550Leufs*3 (c.1648_1649insT); Zygosity=Homozygous (from parent cell line).
Disease Plasma cell myeloma (NCIt: C3242)
Multiple myeloma (ORDO: Orphanet_29073)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0566 (U266B1)
Sex of cell Male
Age at sampling 53Y
Category Cancer cell line
Publications

PubMed=9762409; DOI=10.1080/15216549800203332
Li-Mei Zhou, Shan-Yun Peng, Ju-Bao Duan, Jing Zhou, Li-Hong Wang, Jia-Xi Wang;
A human B cell line AF10 expressing hIL-17.
Biochem. Mol. Biol. Int. 45:1113-1119(1998)

Cross-references
Cell line databases/resources cancercelllines; CVCL_C833
Encyclopedic resources Wikidata; Q54608927
Polymorphism and mutation databases Cosmic; 1070696
Cosmic; 1071879
Cosmic; 1176601
Entry history
Entry creation22-Oct-2012
Last entry update14-Aug-2025
Version number21