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Cellosaurus Py2T (CVCL_C7XI)

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Cell line name Py2T
Accession CVCL_C7XI
Resource Identification Initiative To cite this cell line use: Py2T (RRID:CVCL_C7XI)
Comments Characteristics: Undergoes epithelial-mesenchymal transition (EMT) in response to TGF-beta in vitro (PubMed=23144919).
Genetic integration: Method=Transgenic mouse; Gene=UniProtKB; P03077; Murine polyomavirus (strain A2) (MPyV) middle T antigen (PyMT).
Transformant: NCBI_TaxID; 10636; Murine polyomavirus (strain A2) (MPyV).
Miscellaneous: Age at sampling from personal communication of Christofori, Gerhard M.
Derived from site: In situ; Mammary gland; UBERON=UBERON_0001911.
Cell type: Epithelial cell of mammary gland; CL=CL_0002327.
Disease Malignant neoplasms of the mouse mammary gland (NCIt: C21678)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: FVB/N MMTV-PyMT transgenic.
Sex of cell Female
Age at sampling 12-13W
Category Cancer cell line
STR profile Source(s): Millipore=SCC416

Markers:
Mouse STR 1-110,11
Mouse STR 1-213,17
Mouse STR 2-19
Mouse STR 3-214
Mouse STR 4-219.3
Mouse STR 5-514
Mouse STR 6-415.3
Mouse STR 6-712
Mouse STR 7-129
Mouse STR 8-115
Mouse STR 11-215
Mouse STR 12-120
Mouse STR 13-115.2
Mouse STR 15-320.3
Mouse STR 17-215
Mouse STR 18-317
Mouse STR 19-212
Mouse STR X-126

Run an STR similarity search on this cell line
Publications

PubMed=23144919; DOI=10.1371/journal.pone.0048651; PMCID=PMC3492491
Lorenz Waldmeier, Nathalie Meyer-Schaller, Maren Diepenbruck, Gerhard M. Christofori;
Py2T murine breast cancer cells, a versatile model of TGFbeta-induced EMT in vitro and in vivo.
PLoS ONE 7:e48651.1-e48651.17(2012)

Cross-references
Cell line collections (Providers) Millipore; SCC416
Encyclopedic resources Wikidata; Q123033285
Entry history
Entry creation29-Jun-2023
Last entry update10-Apr-2025
Version number7