| Cell line name |
SW620(MDR1/3) |
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| Synonyms |
SW620MDR1/3 |
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| Accession |
CVCL_C7SP |
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| Resource Identification Initiative |
To cite this cell line use: SW620(MDR1/3) (RRID:CVCL_C7SP) |
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| Comments |
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_91367; Barasertib-HQPA (AZD1152-HQPA).
Omics: Transcriptomics; Microarray.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029. |
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| Sequence variations |
- Mutation; HGNC; HGNC:583; APC; Simple; p.Gln1338Ter (c.4012C>T); ClinVar=VCV000000801; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012583; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro309Ser (c.925C>T); ClinVar=VCV000458575; Zygosity=Heterozygous (from parent cell line).
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| Disease |
Colon adenocarcinoma (NCIt: C4349) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0547 (SW620) |
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| Sex of cell |
Male |
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| Age at sampling |
51Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=19188929; DOI=10.1038/tpj.2008.20
Jun Guo, Mark G. Anderson, Paul Tapang, Joann P. Palma, Luis E. Rodriguez, Amanda L. Niquette, Jun-Ling Li, Jennifer J. Bouska, G. Wang, Dimitri Semizarov, Daniel H. Albert ...Show all 14 authors... , Cherrie K. Donawho, Keith B. Glaser, O. Jameel Shah; Show fewer authors
Identification of genes that confer tumor cell resistance to the aurora B kinase inhibitor, AZD1152.
Pharmacogenomics J. 9:90-102(2009) |
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| Cross-references |
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| Encyclopedic resources |
Wikidata; Q117704902
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| Entry history |
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| Entry creation | 21-Mar-2023 |
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| Last entry update | 10-Apr-2025 |
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| Version number | 5 |
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