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Cellosaurus MCF10A-ERBB2m-10 (CVCL_C7QY)

[Text version]
Cell line name MCF10A-ERBB2m-10
Synonyms MCF10A-ERBB2_type-11; 06M15005
Accession CVCL_C7QY
Resource Identification Initiative To cite this cell line use: MCF10A-ERBB2m-10 (RRID:CVCL_C7QY)
Comments Part of: Fukushima Translational Research Project gene-overexpressing cell lines panel.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:3430; ERBB2 (Note=With p.Val842Ile (c.2524G>A)).
Genetic integration: Method=Transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Derived from site: In situ; Breast, epithelium; UBERON=UBERON_0008367.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0598 (MCF-10A)
Sex of cell Female
Age at sampling 36Y
Category Spontaneously immortalized cell line
Web pages Info; FTRP; -; https://www.fmu.ac.jp/home/trc/en/contract-research-provision/human-gene-overexpressing-cell-lines/
Publications

PubMed=30787176; DOI=10.1158/1535-7163.MCT-18-1085
Hiroki Irie, Kimihiro Ito, Yayoi Fujioka, Kei Oguchi, Akio Fujioka, Akihiro Hashimoto, Hirokazu Ohsawa, Kenji Tanaka, Kaoru Funabashi, Hikari Araki, Yuichi Kawai ...Show all 15 authors... , Tadashi Shimamura, Renu Wadhwa, Shuichi Ohkubo, Kenichi Matsuo; Show fewer authors
TAS0728, a covalent-binding, HER2-selective kinase inhibitor shows potent antitumor activity in preclinical models.
Mol. Cancer Ther. 18:733-742(2019)

Cross-references
Cell line collections (Providers) CancerTools; 161199
Encyclopedic resources Wikidata; Q117704668
Entry history
Entry creation21-Mar-2023
Last entry update10-Apr-2025
Version number5