Cellosaurus cell line MCF10A-ERBB2m-9 (CVCL

Cellosaurus MCF10A-ERBB2m-9 (CVCL_C7QX)

Cross-references
Cell line name	MCF10A-ERBB2m-9
Synonyms	MCF10A-ERBB2_type-10; 06M15004
Accession	CVCL_C7QX
Resource Identification Initiative	To cite this cell line use: MCF10A-ERBB2m-9 (RRID:CVCL_C7QX)
Comments	Part of: Fukushima Translational Research Project gene-overexpressing cell lines panel. Genetic integration: Method=Transduction; Gene=HGNC; HGNC:3430; ERBB2 (Note=With p.Val777Leu (c.2329G>T)). Genetic integration: Method=Transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR). Derived from site: In situ; Breast, epithelium; UBERON=UBERON_0008367.
Sequence variations	Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line). Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0598 (MCF-10A)
Sex of cell	Female
Age at sampling	36Y
Category	Spontaneously immortalized cell line
Web pages	Info; FTRP; -; https://www.fmu.ac.jp/home/trc/en/contract-research-provision/human-gene-overexpressing-cell-lines/
Publications	PubMed=30787176; DOI=10.1158/1535-7163.MCT-18-1085 Hiroki Irie, Kimihiro Ito, Yayoi Fujioka, Kei Oguchi, Akio Fujioka, Akihiro Hashimoto, Hirokazu Ohsawa, Kenji Tanaka, Kaoru Funabashi, Hikari Araki, Yuichi Kawai ...Show all 15 authors... , Tadashi Shimamura, Renu Wadhwa, Shuichi Ohkubo, Kenichi Matsuo; Show fewer authors TAS0728, a covalent-binding, HER2-selective kinase inhibitor shows potent antitumor activity in preclinical models. Mol. Cancer Ther. 18:733-742(2019)
Cell line collections (Providers)	CancerTools; 161198
Encyclopedic resources	Wikidata; Q117704680
Entry history
Entry creation	21-Mar-2023
Last entry update	10-Apr-2025
Version number	5