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Cellosaurus W.Hb12 (CVCL_C7PV)

[Text version]
Cell line name W.Hb12
Synonyms Hb12
Accession CVCL_C7PV
Resource Identification Initiative To cite this cell line use: W.Hb12 (RRID:CVCL_C7PV)
Comments Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:990; BCL2.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Transformant: NCIt; C17262; X-Ray.
Derived from site: In situ; Thymus; UBERON=UBERON_0002370.
Disease Mouse thymoma (NCIt: C198577)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: BALB/c.
Hierarchy Parent: CVCL_3950 (WEHI-7.2)
Category Cancer cell line
Publications

PubMed=8022822; DOI=10.1073/pnas.91.14.6569; PMCID=PMC44244
Minh Lam, George R. Dubyak, Lie Chen, Gabriel Nunez, Roger L. Miesfeld, Clark William Distelhorst;
Evidence that BCL-2 represses apoptosis by regulating endoplasmic reticulum-associated Ca2+ fluxes.
Proc. Natl. Acad. Sci. U.S.A. 91:6569-6573(1994)

PubMed=9371519
Angela Baker, Claire M. Payne, Margaret M. Briehl, Garth Powis;
Thioredoxin, a gene found overexpressed in human cancer, inhibits apoptosis in vitro and in vivo.
Cancer Res. 57:5162-5167(1997)

PubMed=12203227; DOI=10.1002/nbm.790
Norbert W. Lutz, Margaret Ellen Tome, Nanci R. Aiken, Margaret M. Briehl;
Changes in phosphate metabolism in thymoma cells suggest mechanisms for resistance to dexamethasone-induced apoptosis. A 31P NMR spectroscopic study of cell extracts.
NMR Biomed. 15:356-366(2002)

PubMed=15702245; DOI=10.3892/ijmm.15.3.497
Margaret Ellen Tome, Margaret M. Briehl, Norbert W. Lutz;
Increasing the antioxidant defense in WEHI7.2 cells results in a more tumor-like metabolic profile.
Int. J. Mol. Med. 15:497-501(2005)

Cross-references
Encyclopedic resources Wikidata; Q117704964
Entry history
Entry creation21-Mar-2023
Last entry update14-Aug-2025
Version number5