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Cellosaurus DKFZ-BT317 (CVCL_C7GW)

[Text version]
Cell line name DKFZ-BT317
Accession CVCL_C7GW
Resource Identification Initiative To cite this cell line use: DKFZ-BT317 (RRID:CVCL_C7GW)
Comments Characteristics: Transduced with a doxycycline-inducible system coding for SV40 large T antigen and GFP (PubMed=35977048).
Senescence: Withdrawal of doxycycline leads to senescence (PubMed=35977048).
Genetic integration: Method=Transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Derived from site: In situ; Brain; UBERON=UBERON_0000955.
Sequence variations
Disease Pilocytic astrocytoma (NCIt: C4047)
Pilocytic astrocytoma (ORDO: Orphanet_251612)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 2Y
Category Cancer cell line
Publications

PubMed=35977048; DOI=10.1093/neuonc/noac199; PMCID=PMC10076946
Florian Selt, Romain Sigaud, Gintvile Valinciute, Philipp Sievers, Julia Zaman, Clara Alco, Simone Schmid, Heike Peterziel, Jessica W. Tsai, Romain Guiho, Juan Pedro Martinez-Barbera ...Show all 28 authors... , Stefan Pusch, Jing Deng, Yi-Fan Zhai, Cornelis M. van Tilburg, Martin U. Schuhmann, Ahmed El Damaty, Pratiti Bandopadhayay, Christel Herold-Mende, Andreas von Deimling, Stefan Michael Pfister, Joan Montero, David Capper, Ina Oehme, Felix Sahm, David T.W. Jones, Olaf Witt, Till Milde; Show fewer authors
BH3 mimetics targeting BCL-XL impact the senescent compartment of pilocytic astrocytoma.
Neuro-oncol. 25:735-747(2023)

Cross-references
Encyclopedic resources Wikidata; Q117704287
Entry history
Entry creation21-Mar-2023
Last entry update14-Aug-2025
Version number5