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Cellosaurus A549-IR3 (CVCL_C7GS)

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Cell line name A549-IR3
Accession CVCL_C7GS
Resource Identification Initiative To cite this cell line use: A549-IR3 (RRID:CVCL_C7GS)
Comments Population: Caucasian.
Characteristics: Irradiated 3 times with 4 Gy and with at least a three-week interval between each two consecutive irradiations (PubMed=35976051).
Doubling time: 23.07 hours (PubMed=35976051).
Selected for resistance to: NCIt; C129640; Cobalt-60 gamma radiation.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Ser (c.34G>A); ClinVar=VCV000012584; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0023 (A-549)
Sex of cell Male
Age at sampling 58Y
Category Cancer cell line
Publications

PubMed=35976051; DOI=10.1080/09553002.2022.2113837
Avgi Tsolou, Dimitrios Koparanis, Ioannis Lamprou, Alexandra Giatromanolaki, Michael I. Koukourakis;
Increased glucose influx and glycogenesis in lung cancer cells surviving after irradiation.
Int. J. Radiat. Biol. 99:692-701(2023)

Cross-references
Encyclopedic resources Wikidata; Q123030363
Entry history
Entry creation21-Mar-2023
Last entry update19-Dec-2024
Version number4