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Cellosaurus FE1 (CVCL_C6KP)

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Cell line name FE1
Accession CVCL_C6KP
Resource Identification Initiative To cite this cell line use: FE1 (RRID:CVCL_C6KP)
Comments Characteristics: Can be employed for in vitro mutagenicity assessment. Established from a MutaMouse that contains 40 copies of the lacZ reporter gene in a single locus on chromosome 3.
Doubling time: 18.7 +- 1.2 hours (PubMed=14556224).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00722; Escherichia coli beta-galactosidase (lacZ).
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Cell type: Epithelial cell; CL=CL_0000066.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: MutaMouse 40.6.
Sex of cell Male
Age at sampling Adult
Category Spontaneously immortalized cell line
Publications

PubMed=14556224; DOI=10.1002/em.10185
Paul A. White, George R. Douglas, John Gingerich, Craig Leroy John Parfett, Phil Shwed, Vern Seligy, Lynda Soper, M. Lynn Berndt-Weis, Janet Bayley, Shelley Wagner, Kathleen Pound, David H. Blakey;
Development and characterization of a stable epithelial cell line from Muta Mouse lung.
Environ. Mol. Mutagen. 42:166-184(2003)

PubMed=19406224; DOI=10.1016/j.tiv.2009.04.008
M. Lynn Berndt-Weis, Lisa Marie Kauri, Andrew Williams, Paul A. White, George Douglas, Carole Yauk;
Global transcriptional characterization of a mouse pulmonary epithelial cell line for use in genetic toxicology.
Toxicol. In Vitro 23:816-833(2009)

PubMed=28843037; DOI=10.1002/em.22125
Rebecca M. Maertens, Alexandra S. Long, Paul A. White;
Performance of the in vitro transgene mutation assay in MutaMouse FE1 cells: evaluation of nine misleading ('false') positive chemicals.
Environ. Mol. Mutagen. 58:582-591(2017)

Cross-references
Encyclopedic resources Wikidata; Q116049010
Gene expression databases ArrayExpress; E-MEXP-1054
Entry history
Entry creation15-Dec-2022
Last entry update10-Apr-2025
Version number5