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Cellosaurus K/VP.5 (CVCL_C6JT)

[Text version]
Cell line name K/VP.5
Accession CVCL_C6JT
Resource Identification Initiative To cite this cell line use: K/VP.5 (RRID:CVCL_C6JT)
Comments Population: Caucasian.
Doubling time: 22 hours (PubMed=8142256).
Selected for resistance to: ChEBI; CHEBI_4911; Etoposide (VP-16).
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln136fs*13 (c.406_407insC); Zygosity=Homozygous (from parent cell line).
Disease Blast phase chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C9110)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0004 (K-562)
Sex of cell Female
Age at sampling 53Y
Category Cancer cell line
Publications

PubMed=8058057; DOI=10.1016/S0026-895X(25)08668-7
Mary K. Ritke, William P. Allan, Cheryl L. Fattman, Nurten Nur Gunduz, Jack Charles Yalowich;
Reduced phosphorylation of topoisomerase II in etoposide-resistant human leukemia K562 cells.
Mol. Pharmacol. 46:58-66(1994)

PubMed=8142256; DOI=10.1038/bjc.1994.131; PMCID=PMC1968798
Mary K. Ritke, David Roberts, William P. Allan, Jacques Raymond, Vladimir V. Bergoltz, Jack Charles Yalowich;
Altered stability of etoposide-induced topoisomerase II-DNA complexes in resistant human leukaemia K562 cells.
Br. J. Cancer 69:687-697(1994)

Cross-references
Encyclopedic resources Wikidata; Q116049609
Entry history
Entry creation15-Dec-2022
Last entry update19-Dec-2024
Version number5