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Cellosaurus GSC-326 (CVCL_C6IR)

[Text version]
Cell line name GSC-326
Accession CVCL_C6IR
Resource Identification Initiative To cite this cell line use: GSC-326 (RRID:CVCL_C6IR)
Comments Group: Cancer stem cell line.
Derived from site: In situ; Brain; UBERON=UBERON_0000955.
Cell type: Mesenchymal stem cell; CL=CL_0000134.
Disease Malignant glioma (NCIt: C4822)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_C6J4 (GSC-326/ALDH1A3-KO.1.1)CVCL_C6J5 (GSC-326/ALDH1A3-KO.2.3)CVCL_C6J6 (GSC-326/ALDH1A3-KO.2.4)
CVCL_C6J7 (GSC-326/ALDH1A3-KO.3.1)CVCL_C6J8 (GSC-326/ALDH1A3-KO.3.4)CVCL_C6J9 (GSC-326/ALDH1A3-KO.3.5)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line

PubMed=23650391; DOI=10.1073/pnas.1221478110
Mao P., Joshi K., Li J.-F., Kim S.-H., Li P.-P., Santana-Santos L., Luthra S., Chandran U.R., Benos P.V., Smith L., Wang M.-D., Hu B., Cheng S.-Y., Sobol R.W., Nakano I.
Mesenchymal glioma stem cells are maintained by activated glycolytic metabolism involving aldehyde dehydrogenase 1A3.
Proc. Natl. Acad. Sci. U.S.A. 110:8644-8649(2013)

PubMed=34934174; DOI=10.1038/s42003-021-02949-7
Li J.-F., Garavaglia S., Ye Z.-F., Moretti A., Belyaeva O.V., Beiser A., Ibrahim M., Wilk A., McClellan S., Klyuyeva A.V., Goggans K.R., Kedishvili N.Y., Salter E.A., Wierzbicki A., Migaud M.E., Mullett S.J., Yates N.A., Camacho C.J., Rizzi M., Sobol R.W.
A specific inhibitor of ALDH1A3 regulates retinoic acid biosynthesis in glioma stem cells.
Commun. Biol. 4:1420.1-1420.16(2021)

Encyclopedic resources Wikidata; Q116049089
Proteomic databases PRIDE; PXD028125
Entry history
Entry creation15-Dec-2022
Last entry update29-Jun-2023
Version number3