Cellosaurus cell line UKRV-Mel-22a (CVCL

Cellosaurus UKRV-Mel-22a (CVCL_C661)

[Text version]

Cell line name

UKRV-Mel-22a

Accession

CVCL_C661

Resource Identification Initiative

To cite this cell line use: UKRV-Mel-22a (RRID:CVCL_C661)

Sequence variations

Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=23851445).
Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (PubMed=23348503; PubMed=23851445).
Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (PubMed=23348503).

Disease

Melanoma (NCIt: C3224)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Originate from same individual

CVCL_C662 ! UKRV-Mel-22b

Sex of cell

Male

Age at sampling

Age unspecified

Category

Cancer cell line

STR profile

Source(s): ESTDAB=ESTDAB-182

Markers:

Amelogenin	X,Y
CSF1PO	11,12
D3S1358	15,16
D5S818	11,12
D7S820	9
D13S317	9,12
FGA	21,24
TH01	9.3
TPOX	8,11
vWA	18

Publications

PubMed=23348503; DOI=10.1126/science.1230062
Susanne Horn, Adina Figl, P. Sivaramakrishna Rachakonda, Christine Fischer, Antje Sucker, Andreas Gast, Stephanie Kadel, Iris Moll, Eduardo Nagore, Kari Hemminki, Dirk Schadendorf, Rajiv Kumar;
TERT promoter mutations in familial and sporadic melanoma.
Science 339:959-961(2013)

PubMed=23851445; DOI=10.1158/1541-7786.MCR-13-0006
Christina Dahl, Claus Christensen, Goran Jonsson, Anders Lorentzen, Mette Louise Skjodt, Ake Borg, Graham Pawelec, Per Guldberg;
Mutual exclusivity analysis of genetic and epigenetic drivers in melanoma identifies a link between p14 ARF and RARbeta signaling.
Mol. Cancer Res. 11:1166-1178(2013)

Cross-references

Cell line databases/resources

cancercelllines; CVCL_C661
ESTDAB; ESTDAB-182

Encyclopedic resources

Wikidata; Q54990618

Polymorphism and mutation databases

Cosmic; 1846717
Cosmic; 2163860
Cosmic; 2686530

Entry history

Entry creation

22-Oct-2012

Last entry update

19-Dec-2024

Version number