Cell line name |
FM93/2 |
Synonyms |
FM-93/2 |
Accession |
CVCL_C617 |
Resource Identification Initiative |
To cite this cell line use: FM93/2 (RRID:CVCL_C617) |
Comments |
Omics: HLA class I peptidome analysis by proteomics. |
Sequence variations |
- Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (PubMed=23851445).
- Mutation; HGNC; 11998; TP53; Simple; p.Gly266Arg (c.795_796GG>AA); Zygosity=Unspecified (PubMed=23851445).
|
HLA typing |
Source: PubMed=15592718
Class I | HLA-A | A*02:01,26:01 | HLA-B | B*40:01,44:02 | HLA-C | C*03:04,05:01 | Class II | HLA-DP | DPB1*04:02,03:01:01 | HLA-DQ | DQB1*03:01:01,05:01 | HLA-DR | DRB1*14:01:01,04:01:01 |
|
Disease |
Cutaneous melanoma (NCIt: C3510) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_9680 (FM93) |
Sex of cell |
Sex unspecified |
Age at sampling |
Age unspecified |
Category |
Cancer cell line |
STR profile |
Source(s): ECACC=13012419; ESTDAB=ESTDAB-033
Markers: Run an STR similarity search on this cell line |
Publications | PubMed=15592718; DOI=10.1007/s00262-004-0561-5; PMCID=PMC11032966 Rodriguez T., Mendez R., Roberts C.H., Ruiz-Cabello Osuna F., Dodi I.A., Lopez-Nevot M.A., Paco L., Maleno I., Marsh S.G.E., Pawelec G., Garrido F. High frequency of homozygosity of the HLA region in melanoma cell lines reveals a pattern compatible with extensive loss of heterozygosity. Cancer Immunol. Immunother. 54:141-148(2005) PubMed=23851445; DOI=10.1158/1541-7786.MCR-13-0006 Dahl C., Christensen C., Jonsson G., Lorentzen A., Skjodt M.L., Borg A., Pawelec G., Guldberg P. Mutual exclusivity analysis of genetic and epigenetic drivers in melanoma identifies a link between p14 ARF and RARbeta signaling. Mol. Cancer Res. 11:1166-1178(2013) PubMed=27600516; DOI=10.1007/s00262-016-1897-3; PMCID=PMC5509013 Gloger A., Ritz D., Fugmann T., Neri D. Mass spectrometric analysis of the HLA class I peptidome of melanoma cell lines as a promising tool for the identification of putative tumor-associated HLA epitopes. Cancer Immunol. Immunother. 65:1377-1393(2016) |
Cross-references |
Cell line collections (Providers) |
ECACC; 13012419
|
Cell line databases/resources |
cancercelllines; CVCL_C617
ESTDAB; ESTDAB-033
|
Encyclopedic resources |
Wikidata; Q54835076
|
Polymorphism and mutation databases |
Cosmic; 2163783
|
Entry history |
Entry creation | 22-Oct-2012 |
Last entry update | 02-May-2024 |
Version number | 17 |
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